典型文献
The role of OR51E2 in colon cancer and rectal adenocarcinoma and the potential underlying mechanism
文献摘要：
Objective Short-chain fatty acids (SCFAs) produced by intestinal microbiota influence the pathogenesis and development of several intestinal diseases. OR51E2 is a newly discovered SCFA receptor. At present, research on the link between OR51E2 and intestinal cancer is limited. This study aimed to analyze the relationship between OR51E2 and colorectal cancer.Methods Bioinformatic analysis revealed the OR51E2 protein expression pattern in different parts of the intestine, regulation of related proteins, and immune cell infiltration. The expression pattern and prognostic value of OR51E2 in colon and rectal cancer was determined, and the miRNAs targeting OR51E2 were predicted. Results The expression level of OR51E2 was relatively high in the colon, small intestine, and duodenum. In addition, OR51E2 expression level was significantly reduced in colon and rectal cancer. A positive correlation between OR51E2 and immune cells was observed, which was associated with the survival of patients with colon and rectal cancer (hazard ratio: 1.5). Further, miR-96-5p and miR-1271-5-p were predicted to target OR51E2. Conclusion OR51E2 plays an important positive role in the survival of patients with colon cancer and rectal adenocarcinoma.
文献关键词：
中图分类号：
作者姓名：
Shujia Chen;Siang Wei;Jiwei Wang
作者机构：
Department of Gastroenterology,Panjin Central Hospital Affiliated to Jinzhou Medical University,Panjin 124000,China;Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Gastrointestinal Surgery,Xuzhou Central Hospital,Xuzhou 221009,China
文献出处：
引用格式：
[1]Shujia Chen;Siang Wei;Jiwei Wang-.The role of OR51E2 in colon cancer and rectal adenocarcinoma and the potential underlying mechanism)[J].肿瘤学与转化医学（英文）,2022(03):140-145
A类：
OR51E2
B类：
role,colon,cancer,adenocarcinoma,potential,underlying,mechanism,Objective,Short,chain,fatty,acids,SCFAs,produced,by,intestinal,microbiota,influence,pathogenesis,development,several,diseases,newly,discovered,receptor,At,present,research,link,between,limited,This,study,aimed,analyze,relationship,colorectal,Methods,Bioinformatic,analysis,revealed,expression,pattern,different,parts,intestine,regulation,related,proteins,immune,infiltration,prognostic,value,was,determined,miRNAs,targeting,were,predicted,Results,level,relatively,high,small,duodenum,In,addition,significantly,reduced,positive,correlation,cells,observed,which,associated,survival,patients,hazard,Further,5p,Conclusion,plays,important
AB值：
0.458967
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
