典型文献
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes
文献摘要：
Dear Editor,
The first mitotic division in zygotes is crucial for the begin-ning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the mean-time,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail.
文献关键词：
中图分类号：
作者姓名：
Beili Chen;Jianying Guo;Ting Wang;Qianhui Lee;Jia Ming;Fangfang Ding;Haitao Li;Zhiguo Zhang;Lin Li;Yunxia Cao;Jie Na
作者机构：
Department of Obstetrics and Gynecology,Reproductive Medicine Center,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,China;NHC Key Laboratory of study on abnormal gametes and repro-ductive tract,Anhui Medical University,Hefei 230032,China;School of Medicine,Tsinghua University,Beijing 100084,China;Tsinghua-Peking Center for Life Sciences,Beijing 100084,China;Department of Chemistry,Tsinghua University,Beijing 100084,China;Central Laboratory,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China
文献出处：
引用格式：
[1]Beili Chen;Jianying Guo;Ting Wang;Qianhui Lee;Jia Ming;Fangfang Ding;Haitao Li;Zhiguo Zhang;Lin Li;Yunxia Cao;Jie Na-.Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes)[J].蛋白质与细胞,2022(02):148-154
A类：
totipotent,zygote,chromatids,Eckersley,Maslin,Reichmann,perturbances
B类：
Maternal,heterozygous,mutation,CHEK1,leads,mitotic,arrest,human,zygotes,Dear,Editor,
The,first,division,crucial,begin,ning,life,cycle,After,fertilization,reactivate,both,paternal,maternal,genomes,replicate,reprogram,become,In,mean,female,pronucleus,move,center,merge,Then,metaphase,sister,separate,into,two,daughter,cells,This,sensitive,window,many,may,cause,mitosis,fail
AB值：
0.577874
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
