典型文献
Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants
文献摘要：
Dear Editor,
The COVID-19 pandemic,which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has led to millions of lives lost worldwide.The trimeric spike protein(S)decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2)in the early replication cycle(Zhou P.et al.,2020).Two subunits S1 and S2 are included in the trimeric glycoprotein.S1 subunit is composed of the N-terminal domain(NTD),receptor-binding domain(RBD),and C-terminal domains(CTDO,CTD1,and CTD2)and interacts with ACE2 through RBD.S2 subunit plays key roles in the viral-cell membrane fusion and is divided into fusion peptide(FP),fusion-peptide proximal region(FPPR),heptad repeat 1(HR1),central helix(CH),connector domain(CD),heptad repeat 2(HR2),trans-membrane segment(TM)and the cytoplasmic tail(CT)(Hoffmann et al.,2020;Zhang et al.,2021).After the RBD binding to the receptor,the fusion peptide(FP)of the S2 subunit inserts into the cell membrane.Subse-quently,the HR1 domain is exposed and forms a helix-bundle together with the HR2 domain.Finally,the viral envelope and cell membrane draw close to each other,leading fusion and entry to happen(Cai et al.,2020;Walls et al.,2017).
文献关键词：
中图分类号：
作者姓名：
Xiaorui Xing;Lei Wang;Zhen Cui;Wangjun Fu;Tao Zheng;Lili Qin;Pingju Ge;Aidong Qian;Nan Wang;Shuai Yuan
作者机构：
College of Veterinary Medicine,Jilin Agricultural University,Changchun,130118,China;College of Animal Science and Technology,Jilin Provincial Engineering Research Center of Animal Probiotics,Key Lab of Animal Production,Product Quality and Security,Joint Laboratory of Modern Agricultural Technology International Cooperation,Ministry of Education,Jilin Agricultural University,Changchun,130118,China;CAS Key Laboratory of Infection and Immunity,National Laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100101,China;Acrobiosystems,Beijing,100101,China;State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China
文献出处：
引用格式：
[1]Xiaorui Xing;Lei Wang;Zhen Cui;Wangjun Fu;Tao Zheng;Lili Qin;Pingju Ge;Aidong Qian;Nan Wang;Shuai Yuan-.Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants)[J].中国病毒学,2022(06):938-941
A类：
CTDO,CTD1,CTD2,FPPR,heptad
B类：
Structures,SARS,CoV,spike,alert,noteworthy,sites,potential,approaching,variants,Dear,Editor,
The,pandemic,which,is,caused,by,severe,acute,respiratory,syndrome,coronavirus,has,led,millions,lives,lost,worldwide,trimeric,decorating,membrane,surface,infectious,virion,responsible,attachment,entry,binding,receptor,angiotensin,converting,enzyme,ACE2,early,replication,cycle,Zhou,Two,subunits,S1,S2,are,included,glycoprotein,composed,terminal,NTD,RBD,domains,interacts,through,plays,key,roles,viral,cell,fusion,divided,into,peptide,proximal,region,repeat,HR1,central,helix,CH,connector,CD,HR2,trans,segment,TM,cytoplasmic,tail,Hoffmann,Zhang,After,inserts,Subse,quently,exposed,forms,bundle,together,Finally,envelope,draw,close,each,other,leading,happen,Cai,Walls
AB值：
0.563454
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
