典型文献
Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
文献摘要：
Bone defects caused by trauma,tumor,or osteoarthritis remain challenging due to the lack of effective treatments in clinic.Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect.The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles,since the shortcomings of direct injection of stem cells into target tissues.Here,we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology.The designed core-shell microcapsules showed a high cell viability during the culture pro-cedure.In addition,the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects.This study indicated that the core-shell biomass microcap-sules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.
文献关键词：
中图分类号：
作者姓名：
Lei Yang;Yuxiao Liu;Lingyu Sun;Cheng Zhao;Guopu Chen;Yuanjin Zhao
作者机构：
Department of Rheumatology and Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,People's Republic of China;Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,Zhejiang,People's Republic of China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou 325001,Zhejiang,People's Republic of China;State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,People's Republic of China
文献出处：
引用格式：
[1]Lei Yang;Yuxiao Liu;Lingyu Sun;Cheng Zhao;Guopu Chen;Yuanjin Zhao-.Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair)[J].纳微快报（英文）,2022(01):95-106
A类：
microcap,sules
B类：
Biomass,Microcapsules,Stem,Cell,Encapsulation,Bone,Repair,defects,caused,by,trauma,tumor,osteoarthritis,remain,challenging,due,lack,effective,treatments,clinic,transplantation,emerged,alternative,approach,bone,repair,attracted,widespread,attention,owing,its,excellent,biological,activities,therapy,attempts,this,therapeutic,focus,generation,delivery,vehicles,since,shortcomings,direct,injection,stem,cells,into,target,tissues,Here,developed,novel,core,shell,laden,biomass,using,aqueous,phase,microfluidic,electrospray,technology,designed,microcapsules,showed,high,viability,during,culture,cedure,In,addition,animal,experiments,exhibited,that,have,good,biocompatibility,This,study,indicated,generated,promising,potential,engineering,regenerative,medicine
AB值：
0.614164
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