Chemotherapy is still a kind of important strategy for cancer treatment,but lacking effective delivery system limits the therapeutic outcome.Owing to the excellent biocompatibility,albumin has been employed as drug vehicle;however,it has to face complicated synthesis procedures and still needs an effective technology for the drug delivery evaluation.In this study,a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs;furthermore,the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance imaging.This nanosystem with a stable structure exhibited about 80 nanometer size and 7.7[Mn]mM-1S-1 T1 relaxivity;moreover,the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer therapy.Moreover,the nanocomposites effectively entered into the cancer cells and showed superior antitumor ability;and these treated cells exhibited significant T1 signal.These results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.

Qiaoying Wang;Jiali Cai;Zihan Xu;Shihui Huang;Ruiping Zhou;Zhiyong Wang

Leshan Vocational and Technical College,Leshan 614000,China;Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education,School of Materials Science and Engineering,Center for Functional Biomaterials,Sun Yat-sen University,Guangzhou 510275,China;Department of stomatology,Shenzhen Yantian District People's Hospital,Shenzhen 518081,China

仿生工程学报（英文版）

[1]Qiaoying Wang;Jiali Cai;Zihan Xu;Shihui Huang;Ruiping Zhou;Zhiyong Wang-.Albumin-based Theranostic Nanosystem for Drug Controlled Release and Magnetic Resonance Imaging Guided Therapy)[J].仿生工程学报（英文版）,2022(01):188-196

Nanosystem,albumins,relaxivity

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