Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La3+ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3D printing.La3+was successfully introduced into the OCP crystal structure and substituted Ca2+at the Ca-5 and Ca-8 sites.In particular,some La3+ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca8H2(PO4)6·5H2O)crystals and nanoparticles played as the carriers for La3+ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La3+.The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La3+concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promot-ing the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering.

Key Laboratory of Optoelectronic Materials Chemical and Physics,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,155 West Yangqiao Road,Fuzhou 350002,China;University of Chinese Academy of Sciences,Beijing 100049,China;Orthopedics Department,Fujian Medical University Union Hospital,Fuzhou 350001,China

[1]Zeya Xu;Bin Lin;Chaoqian Zhao;Yanjin Lu;Tingting Huang;Yan Chen;Jungang Li;Rongcan Wu;Wenge Liu;Jinxin Lin-.Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering)[J].材料科学技术（英文版）,2022(23):229-242

octacalcium,La3+ions,La3+was,Ca2+at,Ca8H2,La3+concentration

Lanthanum,doped,phosphate,polylactic,acid,fabricated,by,printing,bone,tissue,engineering,has,tremendous,treatment,prevention,diseases,especially,osteoporosis,metabolic,disorders,However,controlling,its,distribution,keeping,release,sustained,steady,body,still,big,challenge,In,this,study,prepared,OCP,powders,via,precipitation,method,further,PLA,porous,scaffolds,successfully,introduced,into,structure,substituted,sites,particular,some,were,deposited,surface,nanoparticles,Both,PO4,5H2O,crystals,carriers,displayed,obvious,mineralization,effects,contained,uniform,rough,micro,topography,which,acted,suitable,pathway,BMSCs,cells,adhere,grow,proliferation,At,certain,extracts,from,increased,expression,osteogenesis,related,thus,promot,osteogenic,differentiation,Moreover,regulated,immune,responses,experiment,vivo,proved,that,safe,could,enhance,defect,regeneration,These,findings,suggest,printed,have,promising,potentials

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