For wound healing, wound infection caused by bacteria is one of the important reasons that delay wound healing process. Therefore, it is very meaningful to develop a multifunctional wound dressing with antibacterial capability to accelerate wound healing. Sodium alginate (SA) and carboxymethyl chitosan (CMCS) are the most commonly used compositions in wound dressing, but their poor stability inhibits the further applications. Introducing CMCS and using cerium ions (Ce3+) to crosslink CMCS and SA to form SA-CMCS hybrid spheres by electrostatic spray method, can not only improve the stability of SA hydrogels, but also endow the spheres with excellent antibacterial properties due to the characteristics of Ce3+. The gradual release of Ce3+ from the SA-CMCS spheres can effectively inhibit the growth of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Combining the wound healing promotion ability of SA and CMCS, this kind of wound dressing can not only avoid wound infection caused by bacteria effectively, but also accelerate wound healing, thus it is an easily prepared material with po-tential applications in skin defect repair.

Tengfei Ma;Xinyun Zhai;Yongkang Huang;Mengzhen Zhang;Pengfei Li;Yaping Du

Tianjin Key Lab for Rare Earth Materials and Applications,Center for Rare Earth and Inorganic Functional Materials,School of Materials Science and Engineering,National Institute for Advanced Materials,Nankai University,Tianjin 300350,China;College of Chemistry,Nankai University,Tianjin 300350,China;Center for Organic Chemistry,Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an 710054,China

稀土学报（英文版）

[1]Tengfei Ma;Xinyun Zhai;Yongkang Huang;Mengzhen Zhang;Pengfei Li;Yaping Du-.Cerium ions crosslinked sodium alginate-carboxymethyl chitosan spheres with antibacterial activity for wound healing)[J].稀土学报（英文版）,2022(09):1407-1416

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