典型文献
Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type Ⅱ diabetic rats
文献摘要：
The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type Ⅱ diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of liver. In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.
文献关键词：
中图分类号：
作者姓名：
Tingting Wang;Lin Zheng;Shuguang Wang;Mouming Zhao;Xiaoling Liu
作者机构：
College of Light Industry and Food Engineering,Guangxi University,Nanning 530004,China;Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center,Guangzhou 510650,China;School of Food Science and Engineering,South China University of Technology,Guangzhou 510640,China
文献出处：
引用格式：
[1]Tingting Wang;Lin Zheng;Shuguang Wang;Mouming Zhao;Xiaoling Liu-.Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type Ⅱ diabetic rats)[J].食品科学与人类健康（英文）,2022(06):1614-1622
A类：
Cucumaria,SCGH
B类：
Anti,diabetic,anti,hyperlipidemic,effects,sea,cucumber,frondosa,gonad,hydrolysates,type,rats,present,study,investigated,activity,potential,mechanisms,model,diabetes,induced,by,streptozotocin,STZ,combined,high,fat,diet,HFD,Results,showed,that,significantly,reduced,water,intake,fasting,blood,glucose,level,glycated,hemoglobin,Moreover,oral,tolerance,insulin,resistance,plasma,were,also,alleviated,Furthermore,histological,analysis,effectively,protected,tissue,structure,liver,In,addition,studies,improved,metabolism,activating,IRS,Akt,signaling,pathway,promoted,AMPK,summary,these,findings,suggested,have,improving,disorders
AB值：
0.562324
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
