Diabetes-associated liver injury becomes a dominant hepatopathy,leading to hepatic failure worldwide.The current study was designed to evaluate the ameliorative effects of ginsenoside Rh1(G-Rh1)on liver injury induced by T2DM.A T2DM mod-el was established using C57BL/6 mice through feeding with HFD followed by injection with streptozotocin at 100 mg·kg-1.Then the mice were continuously administered with G-Rh1(5 and 10 mg·kg-1),to explore the protective effects of G-Rh1 against liver injury.Results showed that G-Rh1 exerted significant effects on maintaining the levels of FBG and insulin,and ameliorated the increased levels of TG,TC and LDL-C induced by T2DM.Moreover,apoptosis in liver tissue was relieved by G-Rh1,according to histological analysis.Particularly,in diabetic mice,it was observed that not only the increased secretion of G6Pase and PEPCK in the gluconeogen-esis pathway,but also inflammatory factors including NF-κB and NLRP3 were suppressed by G-Rh1 treatment.Furthermore,the un-derlying mechanisms by which G-Rh1 exhibited ameliorative effects was associated with its capacity to inhibit the activation of the Akt/FoxO1 signaling pathway induced by T2DM.Taken together,our preliminary study demonstrated the potential mechnism of G-Rh1 in protecting the liver against T2DM-induced damage.

SU Wen-Ya;FAN Mei-Ling;LI Ying;HU Jun-Nan;CAI En-Bo;ZHU Hong-Yan;SONG Ming-Jie;LI Wei

College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China;Maternity Diagnosis&Treatment Center,the Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;National&Local Joint Engineering Research Center for Ginseng Breeding and Development,Changchun 130118,China

中国天然药物

[1]SU Wen-Ya;FAN Mei-Ling;LI Ying;HU Jun-Nan;CAI En-Bo;ZHU Hong-Yan;SONG Ming-Jie;LI Wei-.20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway)[J].中国天然药物,2022(09):669-678

gluconeogen,mechnism

ginsenoside,Rh1,alleviates,T2DM,induced,liver,injury,Akt,FOXO1,pathway,Diabetes,associated,becomes,dominant,hepatopathy,leading,hepatic,failure,worldwide,current,study,was,designed,evaluate,ameliorative,effects,by,mod,established,using,C57BL,mice,through,feeding,HFD,followed,injection,streptozotocin,Then,were,continuously,administered,explore,protective,against,Results,showed,that,exerted,significant,maintaining,levels,FBG,insulin,ameliorated,increased,LDL,Moreover,apoptosis,tissue,relieved,according,histological,analysis,Particularly,diabetic,observed,not,only,secretion,G6Pase,PEPCK,esis,but,also,inflammatory,factors,including,NLRP3,suppressed,treatment,Furthermore,un,derlying,mechanisms,which,exhibited,its,capacity,inhibit,activation,FoxO1,signaling,Taken,together,our,preliminary,demonstrated,potential,protecting,damage

0.558525