典型文献
Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation
文献摘要：
Objective:The purpose of this study is to investigate the anti-diabetic effects of linarin,a flavonoid extracted from Chrysanthemi Indici Flos(CIF),and its potential mechanisms.Methods:The effects of linarin on cell viability and glucose consumption in HepG2 cells were measured.Meanwhile,monosodium glutamate(MSG)mouse model was constructed to monitor the changes of insulin tolerance,glucose tolerance,triglyceride and cholesterol.The protein expression levels of p-AMPK,p-ACC,PEPCK and p-GS were detected by Western blot.Results:Linarin could increase the relative glucose consumption of HepG2 cells,improve insulin toler-ance and glucose tolerance,and decrease the levels of triglyceride and cholesterol of MSG mice.Simultaneously,the expression levels of p-AMPK and p-ACC in HepG2 cells and the liver tissue of MSG mice were increased,while the expression levels of PEPCK and p-GS were decreased after treatment with linarin.Conclusion:Insulin resistance could be ameliorated by linarin in type 2 diabetes,and its mechanism may be related to AMPK signaling pathway.
文献关键词：
中图分类号：
作者姓名：
Zhenji Wang;Zhe Bai;Jinghua Yan;Tengteng Liu;Yingmei Li;Jiahui Xu;Xiaoqian Meng;Yuefeng Bi
作者机构：
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou 450001,China
文献出处：
引用格式：
[1]Zhenji Wang;Zhe Bai;Jinghua Yan;Tengteng Liu;Yingmei Li;Jiahui Xu;Xiaoqian Meng;Yuefeng Bi-.Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation)[J].中草药（英文版）,2022(01):97-103
A类：
linarin,Chrysanthemi,Indici,Linarin
B类：
Anti,diabetic,effects,from,Flos,AMPK,activation,Objective,purpose,this,study,investigate,anti,flavonoid,extracted,CIF,its,potential,mechanisms,Methods,viability,glucose,consumption,HepG2,cells,were,measured,Meanwhile,monosodium,glutamate,MSG,mouse,model,was,constructed,monitor,changes,insulin,tolerance,triglyceride,cholesterol,protein,expression,levels,ACC,PEPCK,GS,detected,by,blot,Results,could,relative,improve,mice,Simultaneously,liver,tissue,increased,decreased,after,treatment,Conclusion,Insulin,resistance,ameliorated,type,diabetes,may,related,signaling,pathway
AB值：
0.452256
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