典型文献
The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway
文献摘要：
The excess deposition of underlying extracellular matrix(ECM)in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes.Anti-fibrosis therapy has received much attention in the treatment of metabolic disorders.Orosomucoid(ORM)is an acute-phase protein mainly produced by liver,which is also an adipokine.In this study,we investigated the effects of ORM on adipose tissue fibrosis and the potential mechanisms.We showed that ORM 1-deficient mice exhibited an obese phenotype,manifested by excessive collagen deposition in adipose tissues and elevated expression of ECM regulators such as metalloproteinases(MMP-2,MMP-13,MMP-14)and tissue inhibitors of metalloproteinases(TIMP-1,TIMP-2,TIMP-3).Administration of exogenous ORM(50mg·kg-1·d-1,ip)for 7 consecutive days in high-fat diet(HFD)-fed mice and leptin receptor(LepR)-deficient db/db mice attenuated these abnormal expressions.Meanwhile,ORM administration stimulated AMP-activated protein kinase(AMPK)phosphorylation and decreased transforming growth factor-β1(TGF-β1)level in adipose tissues of the mice.In TGF-β1-treated 3T3-L1 fibroblasts,ORM(10 μg/mL)improved the impaired expression profiles of fibrosis-related genes,whereas a selective AMPK inhibitor dorsomorphin(1 μmol/mL)abolished these effects.Together,our results suggest that ORM exerts a direct anti-fibrosis effect in adipose tissue via AMPK activation.ORM is expected to become a novel target for the treatment of adipose tissue fibrosis.
文献关键词：
中图分类号：
作者姓名：
Peng-yuan Wang;Jia-yi Feng;Zhen Zhang;Yi Chen;Zhen Qin;Xian-min Dai;Jie Wei;Bo-han Hu;Wei-dong Zhang;Yang Sun;Xia Liu
作者机构：
School of Pharmacy,Second Military Medical University/Naval Medical University,Shanghai 200433,China
文献出处：
引用格式：
[1]Peng-yuan Wang;Jia-yi Feng;Zhen Zhang;Yi Chen;Zhen Qin;Xian-min Dai;Jie Wei;Bo-han Hu;Wei-dong Zhang;Yang Sun;Xia Liu-.The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway)[J].中国药理学报（英文版）,2022(02):367-375
A类：
orosomucoid,Orosomucoid
B类：
adipokine,alleviates,adipose,fibrosis,AMPK,pathway,deposition,underlying,extracellular,matrix,ECM,defined,that,major,contributor,metabolic,such,obesity,diabetes,Anti,therapy,received,much,attention,treatment,disorders,ORM,acute,phase,mainly,produced,by,liver,which,also,In,this,study,investigated,effects,potential,mechanisms,We,showed,deficient,mice,exhibited,obese,phenotype,manifested,excessive,collagen,tissues,elevated,regulators,metalloproteinases,MMP,inhibitors,TIMP,Administration,exogenous,50mg,consecutive,days,high,fat,diet,HFD,fed,leptin,receptor,LepR,db,attenuated,these,abnormal,expressions,Meanwhile,administration,stimulated,activated,kinase,phosphorylation,decreased,transforming,growth,TGF,level,treated,3T3,L1,fibroblasts,improved,impaired,profiles,related,genes,whereas,selective,dorsomorphin,abolished,Together,our,results,suggest,exerts,direct,anti,activation,expected,become,novel,target
AB值：
0.524742
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