典型文献
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development
文献摘要：
INTRODUCTION
In addition to its structural function, the collagen-rich extra-cellular matrix (ECM) of bone has important role in establishing and maintaining cellular organization through control of proliferation, migration, differentiation, and remodeling.1–3 These ECM functions are controlled by receptor-mediated interactions with progenitor cells. Disruption of cell-ECM interactions has been implicated in a wide spectrum of human skeletal disorders, including skeletal dysplasias, chondrodyspla-sias, osteoarthritis, and osteoporosis.1,4–6 Specific interactions between collagens and skeletal progenitors are mediated by cell-surface receptors, principally β1 integrins and discoidin domain receptors (DDRs).
文献关键词：
中图分类号：
作者姓名：
Fatma F.Mohamed;Chunxi Ge;Randy T.Cowling;Daniel Lucas;Shawn A.Hallett;Noriaki Ono;Abdul-Aziz Binrayes;Barry Greenberg;Renny T.Franceschi
作者机构：
Department of Periodontics&Oral Medicine,University of Michigan,Ann Arbor,MI,USA;Division of Cardiovascular Medicine,University of California at San Diego,San Diego,CA,USA;Division of Experimental Hematology and Cancer Biology,Cincinnati Children's Medical Center,Cincinnati,OH,USA;Department of Pediatrics,Cincinnati Children's Hospital,Cincinnati,OH,USA;Department of Orthodontics&Pediatric Dentistry,University of Michigan,Ann Arbor,MI,USA;Department of Prosthetic Dental Sciences,College of Dentistry,King Saud University,Riyadh,Saudi Arabia;Department of Biological Chemistry,School of Medicine,University of Michigan,Ann Arbor,MI,USA;Department of Biomedical Engineering,University of Michigan,Ann Arbor,MI,USA
文献出处：
引用格式：
[1]Fatma F.Mohamed;Chunxi Ge;Randy T.Cowling;Daniel Lucas;Shawn A.Hallett;Noriaki Ono;Abdul-Aziz Binrayes;Barry Greenberg;Renny T.Franceschi-.The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development)[J].骨研究（英文版）,2022(01):178-194
A类：
dysplasias,chondrodyspla,sias,integrins,DDRs
B类：
discoidin,domain,functions,Gli1,positive,skeletal,progenitors,chondrocytes,bone,development,INTRODUCTION,
In,addition,its,structural,rich,extra,cellular,matrix,ECM,has,important,role,establishing,maintaining,organization,through,proliferation,migration,differentiation,remodeling,These,are,controlled,by,mediated,interactions,cells,Disruption,been,implicated,wide,spectrum,human,disorders,including,osteoarthritis,osteoporosis,Specific,between,collagens,surface,receptors,principally
AB值：
0.55432
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
