Yan Zhang;Tao Zuo;Abigail Mc;Vicar;Hui-Lin Yang;Yi-Ping Li;Wei Chen - Department of Pathology,University of Alabama at Birmingham,Birmingham,AL 35294,USA;Key Laboratory of Biomedical Information Engineering of Ministry of Education,Biomedical Informatics and Genomics Center,School of Life Science and Technology,Xi'an Jiaotong University,Xi'an 710049 Shaanxi,P.R.China;Department of Orthopaedics,the First Affiliated Hospital of Soochow University,Orthopaedic Institute of Soochow University,899 Pinghai Road,Suzhou 215031 Jiangsu,P.R.China;Division in Cellular and Molecular Medicine,Department of Pathology and Laboratory Medicine,Tulane University School of Medicine,Tulane University,New Orleans,LA 70112,USA

Chen Kan;Jiazhao Yang;Haitao Fan;Yuanjuan Dai;Xingxing Wang;Rui Chen;Jia Liu;Xiangyue Meng;Wei Wang;Guiling Li;Jiao Zhou;Ya Zhang;Wanbo Zhu;Shiyuan Fang;Haiming Wei;Hong Zheng;Siying Wang;Fang Ni - Department of Pathophysiology,School of Basic Medical Sciences,Anhui Medical University,Hefei,China;Department of Hematology,The First Affiliated Hospital of USTC,The CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China;Institute of Immunology,University of Science and Technology of China,Hefei,China;Department of Orthopaedics,The First Affiliated Hospital of USTC,Hefei,China;Department of Orthopaedics,Fuyang Hospital of Anhui Medical University,Fuyang,China

Zhuang Cui;Hangtian Wu;Ye Xiao;Ting Xu;Junjie Jia;Hancheng Lin;Rongmin Lin;Kun Chen;Yihuang Lin;Kaiqun Li;Xiaohu Wu;Changjun Li;Bin Yu - Division of Orthopaedics and Traumatology,Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,China;Guangdong Provincial Key Laboratory of Bone and Cartilage Regeneration Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,China;Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan 410008,China;Department of Sleep Medicine Center,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

Yu Liu;Xiangxian Zhang;Wei Wang;Ting Liu;Jun Ren;Siyuan Chen;Tianqi Lu;Yan Tie;Xia Yuan;Fei Mo;Jingyun Yang;Yuquan Wei;Xiawei Wei - Laboratory of Aging Research and Cancer Drug Target,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,No.17,Block 3,Southern Renmin Road,Chengdu,Sichuan 610041,PR China;Department of Clinical Laboratory,The West China Second University Hospital of Sichuan University(WCSUH-SCU),Sichuan University,No.17,Block 3,Southern Renmin Road,Chengdu,Sichuan 610041,PR China;Department of Prenatal Diagnosis Center,The West China Second University Hospital of Sichuan University(WCSUH-SCU),Sichuan University,No.17,Block 3,Southern Renmin Road,Chengdu,Sichuan 610041,PR China

Yugo Morita;Motoo Saito;Javier Rangel-Moreno;Anthony M.Franchini;John R.Owen;John C.Martinez;John L.Daiss;Karen L.de Mesy Bentley;Stephen L.Kates;Edward M.Schwarz;Gowrishankar Muthukrishnan - Center for Musculoskeletal Research,University of Rochester Medical Center,Rochester,NY,USA;Division of Allergy,Immunology and Rheumatology,Department of Medicine,University of Rochester Medical Center,Rochester,NY,USA;Department of Environmental Medicine,University of Rochester School of Medicine and Dentistry,Rochester,NY,USA;Department of Orthopedic Surgery,Virginia Commonwealth University,Richmond,VA,USA;Department of Orthopedics,University of Rochester Medical Center,Rochester,NY,USA;Department of Pathology and Laboratory Medicine,University of Rochester Medical Center,Rochester,NY,USA

Qianju Wu;Longwei Hu;Ran Yan;Junfeng Shi;Hao Gu;Yuwei Deng;Ruixue Jiang;Jin Wen;Xinquan Jiang - Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University,National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, China;Stomatological Hospital of Xiamen Medical College, Xiamen, Fujian 361008, China;Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, China

Biagio Palmisano;Rossella Labella;Samantha Donsante;Cristina Remoli;Emanuela Spica;Ilenia Coletta;Giorgia Farinacci;Michele Dello Spedale Venti;Isabella Saggio;Marta Serafini;Pamela Gehron Robey;Alessro Corsi;Mara Riminucci - Department of Molecular Medicine,Sapienza University of Rome,Rome 00161,Italy;Tettamanti Research Center,Department of Pediatrics,University of Milano Bicocca/Fondazione MBBM,Monza 20900,Italy;Department of Biology and Biotechnology,Sapienza University of Rome,Rome 00185,Italy;Institute of Structural Biology and School of Biological Sciences Nanyang Technological University,639798 Singapore,Singapore;CNR Institute of Molecular Biology and Pathology,Piazzale Aldo Moro 5,Rome 00185,Italy;Skeletal Biology Section,National Institute of Dental and Craniofacial Research,National Institutes of Health,Department of Health and Human Services,Bethesda,MD 20892,USA

Takehito Ono;Ryosuke Denda;Yuta Tsukahara;Takashi Nakamura;Kazuo Okamoto;Hiroshi Takayanagi;Tomoki Nakashima - Department of Cell Signaling,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University(TMDU),Yushima 1-5-45,Bunkyo-ku,Tokyo 113-8549,Japan;Department of Orthopaedic Surgery,The Jikei University School of Medicine,3-25-8 Nishi-Shimbashi,Minato-ku,Tokyo 105-8461,Japan;School of Dentistry,Tokyo Medical and Dental University(TMDU),Yushima 1-5-45,Bunkyo-ku,Tokyo 113-8549,Japan;Department of Biochemistry,Tokyo Dental College,Kandamisakicho 2-9-18,Chiyoda-ku,Tokyo 101-0061,Japan;Department of Osteoimmunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Hongo 7-3-1,Bunkyo-ku,Tokyo 113-0033,Japan;Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Hongo 7-3-1,Bunkyo-ku,Tokyo 113-0033,Japan

Dezhi Zhao;Rui Hua;Manuel A.Riquelme;Hongyun Cheng;Teja Guda;Huiyun Xu;Sumin Gu;Jean X.Jiang - Department of Biochemistry and Structural Biology,University of Texas Health Science Center,San Antonio,TX,USA;School of Life Sciences,Northwestern Polytechnical University,Xi'an,China;Department of Biomedical Engineering and Chemical Engineering,University of Texas,San Antonio,TX,USA

Xinhua Li;Shuting Yang;Gongsheng Yuan;Dian Jing;Ling Qin;Hu Zhao;Shuying Yang - Department of Basic and Translational Sciences,School of Dental Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA;Department of Orthopedics,Shanghai General Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,P.R.China;Department of Spinal Surgery,East Hospital,Tongji University,School of Medicine,Shanghai 200120,China;Department of Restorative Sciences,College of Dentistry,Texas A&M University,Dallas,TX,USA;Department of Orthopedic Surgery,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA;The Penn Center for Musculoskeletal Disorders,School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA;Center for Innovation&Precision Dentistry,School of Dental Medicine,School of Engineering and Applied Sciences,University of Pennsylvania,Philadelphia,PA 19104,USA

Dong Guo;Chuangxin Lin;Yuheng Lu;Hong Guan;Weizhong Qi;Hongbo Zhang;Yan Shao;Chun Zeng;Rongkai Zhang;Haiyan Zhang;Xiaochun Bai;Daozhang Cai - Department of Joint Surgery,Center for Orthopedic Surgery,The Third Affiliated Hospital of Southern Medical University,Guangzhou,China;Department of Orthopedics,Orthopedic Hospital of Guangdong Province,Academy of Orthopedics,Guangdong Province,The Third Affiliated Hospital of Southern Medical University,Guangzhou,China;The Third School of Clinical Medicine,Southern Medical University,Guangzhou,China;Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases,Guangzhou,China;Department of Orthopedic Surgery,Shantou Central Hospital,Affiliated Shantou Hospital of Sun Yat-sen University,Shantou,China;State Key Laboratory of Organ Failure Research,Department of Cell Biology,Southern Medical University School of Basic Medical Sciences,Guangzhou,China

Junxin Lin;Yuwei Yang;Wenyan Zhou;Chao Dai;Xiao Chen;Yuanhao Xie;Shan Han;Huanhuan Liu;Yejun Hu;Chenqi Tang;Varitsara Bunpetch;Dan Zhang;Yishan Chen;Xiaohui Zou;Di Chen;Wanlu Liu;Hongwei Ouyang - Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine,and Department of Orthopedic Surgery of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China;Department of Sports Medicine,Zhejiang University School of Medicine,Hangzhou,China;Zhejiang University-University of Edinburgh Institute,Zhejiang University School of Medicine,and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province,Hangzhou,China;China Orthopedic Regenerative Medicine Group(CORMed),Hangzhou,China;Department of Pathology,Zhejiang University School of Medicine,Hangzhou,China;Clinical Research Center,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China;Center for Reproductive Medicine,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China

Fei Wei;Kendal Flowerdew;Michael Kinzel;Luigi E.Perotti;Jackson Asiatico;Mahmoud Omer;Cice Hovell;Veerle Reumers;Melanie J.Coathup - Biionix Cluster,Department of Internal Medicine,College of Medicine,University of Central Florida,Orlando,FL,USA;Marian University College of Osteopathic Medicine,Indianapolis,IN,USA;Department of Mechanical and Aerospace Engineering,University of Central Florida,Orlando,FL,USA;Imec USA,194 NeoCity Wy,Orlando,FL,USA

Qiwen Li;Ruoshi Xu;Kexin Lei;Quan Yuan - State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

Anja R.Zelmer;Renjy Nelson;Katharina Richter;Gerald J.Atkins - Centre for Orthopaedic and Trauma Research,Faculty of Health and Medical Sciences,University of Adelaide,Adelaide,SA 5000,Australia;Department of Infectious Diseases,Central Adelaide Local Health Network,Adelaide,SA 5000,Australia;Royal Adelaide Hospital,Adelaide,SA 5000,Australia;Richter Lab,Department of Surgery,Basil Hetzel Institute for Translational Health Research,University of Adelaide,Adelaide,SA 5011,Australia

Chunyang Ma;Tianming Du;Xufeng Niu;Yubo Fan - Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China;Department of Biomedical Engineering,Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China;Research Institute of Beihang University in Shenzhen,Shenzhen 518057,China;School of Engineering Medicine,Beihang University,Beijing 100083,China

Liping Tong;Huan Yu;Xingyun Huang;Jie Shen;Guozhi Xiao;Lin Chen;Huaiyu Wang;Lianping Xing;Di Chen - Research Center for Computer-aided Drug Discovery,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518005,China;Faculty of Pharmaceutical Sciences,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Department of Orthopedic Surgery,School of Medicine,Washington University in St.Louis,St.Louis,MO 63110,USA;School of Medicine,Southern University of Science and Technology,Shenzhen 518055,China;Department of Wound Repair and Rehabilitation,State Key Laboratory of Trauma,Burns and Combined Injury,Daping Hospital,Army Medical University,Chongqing 400042,China;Research Center for Human Tissues and Organs Degeneration,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Department of Pathology and Laboratory of Medicine,Center for Musculoskeletal Research,University of Rochester Medical Center,Rochester,NY 14642,USA