典型文献
Role of TRPM2 in brain tumours and potential as a drug target
文献摘要：
Ion channels are ubiquitously expressed in almost all living cells,and are the third-largest category of drug targets,following enzymes and receptors.The transient receptor potential melastatin(TRPM)subfamily of ion channels are important to cell function and survival.Studies have shown upregulation of the TRPM family of ion channels in various brain tumours.Gliomas are the most prevalent form of primary malignant brain tumours with no effective treatment;thus,drug development is eagerly needed.TRPM2 is an essential ion channel for cell function and has important roles in oxidative stress and inflammation.In response to oxidative stress,ADP-ribose(ADPR)is produced,and in turn activates TRPM2 by binding to the NUDT9-H domain on the C-terminal.TRPM2 has been implicated in various cancers and is significantly upregulated in brain tumours.This article reviews the current understanding of TRPM2 in the context of brain tumours and overviews the effects of potential drug therapies targeting TRPM2 including hydrogen peroxide(H2O2),curcumin,docetaxel and selenium,paclitaxel and resveratrol,and botulinum toxin.It is long withstanding knowledge that gliomas are difficult to treat effectively,therefore investigating TRPM2 as a potential therapeutic target for brain tumours may be of considerable interest in the fields of ion channels and pharmacology.
文献关键词：
中图分类号：
作者姓名：
Delphine Ji;Zheng-wei Luo;Andrea Ovcjak;Rahmah Alanazi;Mei-Hua Bao;Zhong-Ping Feng;Hong-Shuo Sun
作者机构：
Department of Surgery,Temerty Faculty of Medicine,University of Toronto,Toronto,ON,Canada;Department of Physiology,Temerty Faculty of Medicine,University of Toronto,Toronto,ON,Canada;Science Research Center,Changsha Medical University,Changsha 410219,China;Department of Pharmacology and Toxicology,Temerty Faculty of Medicine,University of Toronto,Toronto,ON,Canada;Leslie Dan Faculty of Pharmacy,University of Toronto,Toronto,ON,Canada
文献出处：
引用格式：
[1]Delphine Ji;Zheng-wei Luo;Andrea Ovcjak;Rahmah Alanazi;Mei-Hua Bao;Zhong-Ping Feng;Hong-Shuo Sun-.Role of TRPM2 in brain tumours and potential as a drug target)[J].中国药理学报（英文版）,2022(04):759-770
A类：
ADPR,NUDT9
B类：
Role,TRPM2,brain,tumours,potential,drug,Ion,channels,are,ubiquitously,expressed,almost,all,living,cells,third,largest,category,targets,following,enzymes,receptors,transient,melastatin,subfamily,important,function,survival,Studies,have,shown,upregulation,various,Gliomas,prevalent,form,primary,malignant,treatment,thus,development,eagerly,needed,essential,has,roles,oxidative,stress,inflammation,In,response,ribose,produced,turn,activates,by,binding,domain,terminal,been,implicated,cancers,significantly,upregulated,This,article,reviews,current,understanding,context,overviews,effects,therapies,targeting,including,hydrogen,peroxide,H2O2,curcumin,docetaxel,selenium,paclitaxel,resveratrol,botulinum,toxin,It,long,withstanding,knowledge,that,gliomas,difficult,effectively,therefore,investigating,therapeutic,may,considerable,interest,fields,pharmacology
AB值：
0.54201
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
