Gibberellic acid(GA),a ubiquitous phytohormone,has various effects on regulators of plant growth and development.GAs promote growth by overcoming growth restraint mediated by DELLA proteins(DELLAs).DELLAs,in the GRAS family of plant-specific nuclear proteins,are nuclear transcriptional reg-ulators harboring a unique N-terminal GA perception region for binding the GA receptor GIBBERELLIN INSENSITIVE DWARF 1(GID1)and a C-terminal GRAS domain necessary for GA repression activity via interaction with multiple regulatory proteins.The N-terminal conserved region of DELLAs evolved to form a mode of GID1/DELLA-mediated GA signaling originating in bryophytes and ferns.Binding of GA to GID1 increases the affinity between DELLAs and a SCF E3 ubiquitin-ligase complex,thus promoting the eventual destruction of DELLAs by the 26S proteasome.DELLAs negatively regulate GA response by releasing transcription factors to directly activate downstream genes and indirectly regulate GA biosyn-thesis genes increasing GA responsiveness and feedback control by promoting GID1 transcription.GA communicates extensively with other plant hormones and uses crosstalk to regulate plant growth and development.In this review,we summarize current understanding of evolutionary DELLA-mediated gib-berellin signaling and functional diversification of DELLA,focusing primarily on interactions of DELLAs with diverse phytohormones.

Huidan Xue;Xiang Gao;Peng He;Guanghui Xiao

School of Food and Biological Engineering,Shaanxi University of Science and Technology,Xi'an 710021,Shaanxi,China;School of Ecology and Environment,Northwestern Polytechnical University,Xi'an 710012,Shaanxi,China;College of Life Sciences,Shaanxi Normal University,Xi'an 710119,Shaanxi,China

作物学报（英文版）

[1]Huidan Xue;Xiang Gao;Peng He;Guanghui Xiao-.Origin,evolution,and molecular function of DELLA proteins in plants)[J].作物学报（英文版）,2022(02):287-299

DELLAs,GIBBERELLIN,DWARF,communicates,gib,berellin

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