Jian WANG;Liqian SU;Lun ZHANG;Jiali ZENG;Qingru CHEN;Rui DENG;Ziyan WANG;Weidong KUANG;Xiaobao JIN;Shuiqing GUI;Yinghua XU;Xuemei LU-Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances,School of Life Science and Biopharmaceutics,Guangdong Pharmaceutical University,Guangzhou 510006,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;Intensive Care Unit,Shenzhen Second People's Hospital,the First Affiliated Hospital of Shenzhen University,Shenzhen 518031,China;Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,National Institutes for Food and Drug Control,Beijing 102629,China

Jiali Dong;Yuan Li;Huiwen Xiao;Ming Cui;Saijun Fan-Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China;Department of Microbiology,College of Life Sciences,Nankai University,Tianjin 300071,China

Xian Peng;Lei Cheng;Yong You;Chengwei Tang;Biao Ren;Yuqing Li;Xin Xu;Xuedong Zhou-State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,China;Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China;Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu,China;Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu,China

Yunchang Zhang;Xuemeng Si;Ling Yang;Hui Wang;Ye Sun;Ning Liu-Ministry of Agriculture and Rural Affairs,Institute of Feed Research,Chinese Academy of Agricultural Sciences,Beijing,China;State Key Laboratory of Animal Nutrition,Department of Animal Nutrition and Feed Science,China Agricultural University,Beijing,China;Beijing Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing,China;Department of Food and Bioengineering,Beijing Vocational College of Agriculture,Beijing,China;Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences&Comparative Medical Center,Peking Union Medical College,Beijing,China

Jianguo Guo;Chenchen Song;Yunbo Liu;Xuying Wu;Wei Dong;Hua Zhu;Zhiguang Xiang;Chuan Qin-Key Laboratory of Human Disease Comparative Medicine,Chinese Ministry of Health,Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing,China

Dong Yan;Ye Sun;Xiaoyue Zhou;Wenhao Si;Jieyu Liu;Min Li;Minna Wu-Xinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences , Xinxiang Medical University , Xinxiang , China;Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center , Peking Union Medical College , Beijing , China;Department of Dermatology , the First Affiliated Hospital of Xinxiang Medical University , Xinxiang , China

Ruonan Yan;Chi-Tang Ho;Xin Zhang-Department of Food Science and Engineering,Ningbo University,Ningbo 315211,China;Department of Food Science,Rutgers,The State University of New Jersey,NJ 08901,USA

Van-Long Truong;Woo-Sik Jeong-Food and Bio-industry Research Institute,School of Food Science&Biotechnology,College of Agriculture and Life Sciences,Kyungpook National University,Daegu 41566,Korea

Jiaobo Cheng;Jielun Hu;Fang Geng;Shaoping Nie-State Key Laboratory of Food Science and Technology,China-Canada Joint Lab of Food Science and Technology(Nanchang),Nanchang University,Nanchang 330047,China;Key Laboratory of Coarse Cereal Processing(Ministry of Agriculture and Rural Affairs),School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China

Li Hua;Wang Yong;Zhao Changying;Liu Jian;Zhang Lei;Li Anyuan-Department of Gastroenterology, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, China;Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Chancheng District, Foshan, Guangdong 528000, China;Jinan Institute of Paediatric Medicine, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, China;Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250002, China;Department of Traditional Chinese Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China

Bai Xiaoyin;Jiang Lingjuan;Ruan Gechong;Liu Tingting;Yang Hong-Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Liu Zuojing;Zhu Shiwei;He Meibo;Li Mo;Wei Hui;Zhang Lu;Sun Qinghua;Jia Qiong;Hu Nan;Fang Yuan;Song Lijin;Zhou Chen;Tao Heqing;Y Kao John;Zhu Huaiqiu;Owyang Chung;Duan Liping-Department of Gastroenterology, Peking University Third Hospital, Haidian District, Beijing 100191, China;Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing 100191, China;Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China;Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100187, China;Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520 MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA

Liu Qiaoyan;He Wei;Tang Ruqi;Ma Xiong-Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China

Yuan Runxue;Yang Lei;Yao Gaiqi;Geng Shuxia;Ge Qinggang;Bo Shining;Li Xueni-Department of Intensive Care Unit, Peking University Third Hospital, Beijing 100191, China;Peking University Sixth Hospital, Peking University Institute of Mental Health, National Health Council Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100083, China

Wang Yun;Zhang Sheng;Borody Thomas J.;Zhang Faming-Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China;Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, Jiangsu 210011, China;Center for Digestive Diseases, Sydney, NSW 2046, Australia;National Clinical Research Center for Digestive Diseases, Xi’an, Shaanxi 710032, China

ZHANG Huixiang;WANG Limei;GUO Jipeng;WANG Jiai;ZHANG Qianqian;WANG Yutao;LIU Xun;ZHANG Lihuan;SHI Lanlan;WU Hongxiang;CAO Xue-Institute of Neuroscience,Basic Medical College,Kunming Medical University,Kunming 650500,China;Department of Laboratory Animal Science,Kunming Medical University,Kunming 650500,China;School of Electrical and Information Technology,Yunnan Minzu University,Kunming 650500,China;School of Medicine,Kunming University,Kunming 650214,China;Basic Medical College,Kunming Medical University,Kunming 650500,China;Department of Anatomy,Histology and Embryology,Basic Medical College,Kunming Medical University,Kunming 650500,China;Faculty of Rehabilitation Medicine,Kunming Medical University,Kunming 650500,China;Department of Laboratory Animal Science,Kunming Medical University,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan University,Kunming 650500,China

Weiping Jia;Gianni Panagiotou-Shanghai Key Laboratory of Diabetes Mellitus,Department of Endocrinology and Metabolism,Shanghai Diabetes Institute,Shanghai Clinical Center for Diabetes,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China;Systems Biology and Bioinformatics Unit,Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoll Institute,Jena 07745,Germany;State Key Laboratory of Pharmaceutical Biotechnology,The University of Hong Kong,Hong Kong,China;Department of Medicine,The University of Hong Kong,Hong Kong,China

Eugenia Trushina;Sergey Trushin;Md Fayad Hasan-Department of Neurology,Mayo Clinic,Rochester MN 55905,USA;Department of Molecular Pharmacology and Experimental Therapeutics,Mayo Clinic,Rochester MN 55905,USA

Yijing Zhan;Qianmei Liu;Bo Zhang;Xin Huang;Qianjin Lu-Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases,Chinese Academy of Medical Sciences,Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Department of Dermatology,The Second Xiangya Hospital of Central South University,Institute of Dermatology and Venereology of Central South University,Hunan Clinical Medicine Research Center for Major Skin Diseases and Skin Health,Changsha 410011,China

Hai-long Li;Yi-ying Wei;Xiao-he Li;Shan-shan Zhang;Ruo-tong Zhang;Jin-he Li;Bo-wei Ma;Shuai-bo Shao;Zi-wei Lv;Hao Ruan;Hong-gang Zhou;Cheng Yang-The State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy and Key Laboratory of Molecular Drug Research,Nankai University,Tianjin 300350,China;High-throughput Molecular Drug Screening Centre,Tianjin International Joint Academy of Biomedicine,Tianjin 300350,China