典型文献
Pure drug nano-assemblies:A facile carrier-free nanoplatform for efficient cancer therapy
文献摘要：
Nanoparticulate drug delivery systems(Nano-DDSs)have emerged as possible solution to the obstacles of anticancer drug delivery.However,the clinical outcomes and translation are restricted by several drawbacks,such as low drug loading,premature drug leakage and carrier-related toxicity.Recently,pure drug nano-assemblies(PDNAs),fabricated by the self-assembly or co-assembly of pure drug molecules,have attracted considerable attention.Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control,scale-up production and clin-ical translation.Acting as both carriers and cargos,the carrier-free PDNAs have an ultra-high or even 100％drug loading.In addition,combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment,such as tumor metastasis and drug resistance.In the present re-view,the latest development of PDNAs for cancer treatment is overviewed.First,PDNAs are classified according to the composition of drug molecules,and the assembly mechanisms are discussed.Further-more,the co-delivery of PDNAs for combination therapies is summarized,with special focus on the improvement of therapeutic outcomes.Finally,future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted.
文献关键词：
中图分类号：
作者姓名：
Shuwen Fu;Guanting Li;Wenli Zang;Xinyu Zhou;Kexin Shi;Yinglei Zhai
作者机构：
School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Periodontology,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Disease,Shenyang 110016,China;Bio-system Pharmacology,Graduate School of Medicine,Faculty of Medicine,Osaka University,Osaka 565-0871,Japan;Department of Biomedical Engineering,School of Medical Device,Shenyang Pharmaceutical University,Shenyang 110016,China
文献出处：
引用格式：
[1]Shuwen Fu;Guanting Li;Wenli Zang;Xinyu Zhou;Kexin Shi;Yinglei Zhai-.Pure drug nano-assemblies:A facile carrier-free nanoplatform for efficient cancer therapy)[J].药学学报（英文版）,2022(01):92-106
A类：
Nanoparticulate,DDSs,PDNAs,spotlighted
B类：
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AB值：
0.512471
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