典型文献
Structure genomics of SARS-CoV-2 and its Omicron variant:drug design templates for COVID-19
文献摘要：
Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has brought an unprecedented public health crisis and persistently threatens to humanity.With tireless efforts from scientists around the world,understanding of the biology of coronavirus has been greatly enhanced over the past 2 years.Structural biology has demonstrated its powerful impact on uncovering structures and functions for the vast majority of SARS-CoV-2 proteins and guided the development of drugs and vaccines against COVID-19.In this review,we summarize current progress in the structural biology of SARS-CoV-2 and discuss important biological issues that remain to be addressed.We present the examples of structure-based design of Pfizer's novel anti-SARS-CoV-2 drug PF-07321332(Paxlovid),Merck's nucleotide inhibitor molnupiravir(Lagevrio),and W116,an oral drug candidate for COVID-19.These examples highlight the importance of structure in drug discovery to combat COVID-19.We also discussed the recent variants of Omicron and its implication in immunity escape from existing vaccines and antibody therapies.
文献关键词：
中图分类号：
作者姓名：
Can-rong Wu;Wan-chao Yin;Yi Jiang;H.Eric Xu
作者机构：
The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China
文献出处：
引用格式：
[1]Can-rong Wu;Wan-chao Yin;Yi Jiang;H.Eric Xu-.Structure genomics of SARS-CoV-2 and its Omicron variant:drug design templates for COVID-19)[J].中国药理学报（英文版）,2022(12):3021-3033
A类：
tireless,Lagevrio,W116
B类：
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AB值：
0.632388
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