典型文献
Recent advances in the use of the CRISPR-Cas system for the detection of infectious pathogens
文献摘要：
Infectious diseases cause great economic loss and individual and even social anguish. Existing detection methods lack sensitivity and specificity, have a poor turnaround time, and are dependent on expensive equipment. In recent years, the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system has been widely used in the detection of pathogens that cause infectious diseases owing to its high specificity, sensitivity, and speed, and good accessibility. In this review, we discuss the discovery and development of the CRISPR-Cas system, summarize related analysis and interpretation methods, and discuss the existing applications of CRISPR-based detection of infectious pathogens using Cas proteins. We conclude the challenges and prospects of the CRISPR-Cas system in the detection of pathogens.
文献关键词：
中图分类号：
作者姓名：
Hongdan GAO;Zifang SHANG;Siew Yin CHAN;Dongli MA
作者机构：
Institute of Pediatrics,Shenzhen Children's Hospital,Shenzhen 518026,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Frontiers Science Center for Flexible Electronics(FSCFE),Xi'an Institute of Flexible Electronics(IFE)&Xi'an Institute of Biomedical Materials and Engineering(IBME),Northwestern Polytechnical University(NPU),Xi'an 710072,China
引用格式：
[1]Hongdan GAO;Zifang SHANG;Siew Yin CHAN;Dongli MA-.Recent advances in the use of the CRISPR-Cas system for the detection of infectious pathogens)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(11):881-898
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anguish
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AB值：
0.582743
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