典型文献
Proteomic characterization of post-translational modifications in drug discovery
文献摘要：
Protein post-translational modifications(PTMs),which are usually enzymatically catalyzed,are major regulators of protein activity and involved in almost all celluar processes.Dysregulation of PTMs is associated with various types of diseases.Therefore,PTM regulatory enzymes represent as an attractive and important class of targets in drug research and development.Inhibitors against kinases,methyltransferases,deacetyltransferases,ubiquitin ligases have achieved remarkable success in clinical application.Mass spectrometry-based proteomics technologies serve as a powerful approach for system-wide characterization of PTMs,which facilitates the identification of drug targets,elucidation of the mechanisms of action of drugs,and discovery of biomakers in personalized therapy.In this review,we summarize recent advances of proteomics-based studies on PTM targeting drugs and discuss how proteomics strategies facilicate drug target identification,mechanism elucidation,and new therapy development in precision medicine.
文献关键词：
中图分类号：
作者姓名：
Lin-hui Zhai;Kai-feng Chen;Bing-bing Hao;Min-jia Tan
作者机构：
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Zhongshan Institute of Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Science,Zhongshan 528400,China
文献出处：
引用格式：
[1]Lin-hui Zhai;Kai-feng Chen;Bing-bing Hao;Min-jia Tan-.Proteomic characterization of post-translational modifications in drug discovery)[J].中国药理学报（英文版）,2022(12):3112-3129
A类：
enzymatically,celluar,deacetyltransferases,biomakers,facilicate
B类：
Proteomic,characterization,post,translational,modifications,discovery,Protein,PTMs,which,are,usually,catalyzed,major,regulators,protein,activity,involved,almost,processes,Dysregulation,associated,various,types,diseases,Therefore,regulatory,enzymes,represent,attractive,important,class,targets,research,development,Inhibitors,against,kinases,methyltransferases,ubiquitin,ligases,have,achieved,remarkable,success,clinical,application,Mass,spectrometry,proteomics,technologies,serve,powerful,approach,system,wide,facilitates,identification,elucidation,mechanisms,action,drugs,personalized,therapy,this,review,summarize,recent,advances,studies,targeting,discuss,how,strategies,new,precision,medicine
AB值：
0.584276
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