Lung cancer is the leading cause of cancer-related deaths worldwide. Approximately 10%-50% of patients experience relapse after radical surgery, which may be attributed to the persistence of minimal/molecular residual disease (MRD). Circulating tumor DNA (ctDNA), a common liquid biopsy approach, has been demonstrated to have significant clinical merit. In this study, we review the evidence supporting the use of ctDNA for MRD detection and discuss the potential clinical applications of postoperative MRD detection, including monitoring recurrence, guiding adjuvant treatment, and driving clinical trials in lung cancer. We will also discuss the problems that prevent the routine application of ctDNA MRD detection. Multi-analyte methods and identification of specific genetic and molecular alterations, especially methylation, are effective detection strategies and show considerable prospects for future development. Interventional prospective studies based on ctDNA detection are needed to determine whether the application of postoperative MRD detection can improve the clinical outcomes of lung cancer patients, and the accuracy, sensitivity, specificity, and robustness of different detection methods still require optimization and refinement.

circulating tumor DNA;liquid biopsy;lung cancer;minimal/molecular residual disease

Wu Manqi;Shen Haifeng;Wang Ziyang;Kanu Nnennaya;Chen Kezhong

Department of Thoracic Surgery, Peking University People's Hospital, Peking University, Beijing 100044, China;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, 72 Huntley St, London, WC1E 6DD, UK

慢性疾病与转化医学（英文）

[1]Wu Manqi;Shen Haifeng;Wang Ziyang;Kanu Nnennaya;Chen Kezhong-.Research Progress on Postoperative Minimal/Molecular Residual Disease Detection in Lung Cancer)[J].慢性疾病与转化医学（英文）,2022(02):83-90

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