典型文献
Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives
文献摘要：
In recent years,various methods for detecting exogenous and endogenous hypochlorite have been studied,considering its essential role as a biomolecule.However,the existing technologies still pose obstacles such as their invasiveness,high costs,and complicated operation.In the current study,we developed a glow-type chemiluminescent probe,hypochlorite chemiluminescence probe(HCCL)-1,based on the scaffold of Schaap's 1,2-dioxetane luminophores.To better explore the physiological and pathological functions of hypochlorite,we modified the luminophore scaffold of HCCL-1 to develop several probes,including HCCL-2,HCCL-3,and HCCL-4,which amplify the response signal of hypo-chlorite.By comparing the luminescent intensities of the four probes using the IVIS? system,we determined that HCCL-2 with a limit of detection of 0.166 μM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo.
文献关键词：
中图分类号：
作者姓名：
Yingai Sun;Yuqi Gao;Chunchao Tang;Gaopan Dong;Pei Zhao;Dunquan Peng;Tiantian Wang;Lupei Du;Minyong Li
作者机构：
Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(MOE),School of Pharmacy,Shandong University,Jinan,250012,China;School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,510006,China;State Key Laboratory of Microbial Technology,Shandong University,Jinan,250100,China
文献出处：
引用格式：
[1]Yingai Sun;Yuqi Gao;Chunchao Tang;Gaopan Dong;Pei Zhao;Dunquan Peng;Tiantian Wang;Lupei Du;Minyong Li-.Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives)[J].药物分析学报（英文）,2022(03):446-452
A类：
dioxetane,luminophore,HCCL,Schaap
B类：
Multiple,rapid,responsive,probes,hypochlorite,detection,derivatives,In,recent,years,various,methods,detecting,exogenous,endogenous,have,been,studied,considering,its,essential,role,biomolecule,However,existing,technologies,still,pose,obstacles,such,their,invasiveness,high,costs,complicated,operation,current,study,developed,glow,type,chemiluminescent,chemiluminescence,scaffold,luminophores,To,better,explore,physiological,pathological,functions,modified,several,including,which,amplify,response,signal,By,comparing,intensities,four,using,IVIS,system,determined,that,limit,has,enhanced,sensitivity,selectivity,tracking,both,vitro,vivo
AB值：
0.551687
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