典型文献
Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy
文献摘要：
As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological pro-cesses by activating specific target proteins.The importance of calcium ions(Ca2+)makes its"Janus nature"strictly regulated by its concentra-tion.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role."Calcium overload,"for example,is characterized by excessive enrichment of intracellular Ca2+,which irreversibly switches calcium signaling from"positive regulation"to"reverse destruction,"leading to cell death.However,this undesirable death could be defined as"calcicoptosis"to offer a novel approach for cancer treatment.Indeed,Ca2+is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.
文献关键词：
中图分类号：
作者姓名：
Shuang Bai;Yulu Lan;Shiying Fu;Hongwei Cheng;Zhixiang Lu;Gang Liu
作者机构：
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,People's Republic of China;State Key Laboratory of Cellular Stress Biology,Innovation Center for Cell Biology,School of Life Sciences,Xiamen University,Xiamen 361102,People's Republic of China
文献出处：
引用格式：
[1]Shuang Bai;Yulu Lan;Shiying Fu;Hongwei Cheng;Zhixiang Lu;Gang Liu-.Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy)[J].纳微快报（英文）,2022(09):95-131
A类：
calcicoptosis
B类：
Connecting,Calcium,Based,Nanomaterials,Cancer,From,Diagnosis,Therapy,indispensable,second,messenger,calcium,signaling,involved,almost,all,physiological,cesses,by,activating,specific,target,proteins,importance,makes,its,Janus,nature,strictly,regulated,concentra,Abnormal,signals,may,cause,some,diseases,however,artificial,homeostasis,local,lesions,also,play,therapeutic,role,overload,example,characterized,excessive,enrichment,intracellular,which,irreversibly,switches,from,positive,reverse,destruction,leading,death,However,this,undesirable,could,defined,offer,novel,approach,cancer,treatment,Indeed,Ca2+is,various,diagnostic,events,including,induced,disorder,channels,dysregulation,mitochondrial,dysfunction,associated,immunoregulation,vascular,tumor,calcification,mediated,imaging,paral,lel,development,multifunctional,nanomaterials,phosphate,carbonate,peroxide,hydroxyapatite,becoming,abundantly,available,This,review,will,highlight,latest,insights,explain,their,application,provide,perspective,Identifying,characterizing,new,patterns,dependent,exploiting,element,linkage,additional,translational,opportunities,theranostics
AB值：
0.673001
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
