典型文献
Construction and Properties of Simvastatin and Calcium Phosphate Dual-Loaded Coaxial Fibrous Membranes with Osteogenic and Angiogenic Functions
文献摘要：
The ideal Guided Bone Regeneration(GBR)membrane is required to have good biocompatibility,space maintenance ability,appropriate degradation rate,and preferably can guide the regeneration of vascularized bone tissue.In this study,Simvastatin(SIM)and calcium Phosphate(CaP)were encapsulated in a Polycaprolactone(PCL)/Chitosan(CS)core-shell structural fibrous membranes via coaxial electrospinning technology.The results showed that loaded SIM in the core of the core-shell structure fibrous membranes could sustainably release the drug for more than two months and upregulate the angiogenic marker of Bone Mesenchymal Stem Cells(BMSCs).Adding a certain amount of CaP to the shell layer provided more sites for the mineralization and synergistic with SIM to promote osteogenic differentiation of BMSCs in vitro.The intramuscular implantation experiments in rabbits suggested a normal early inflammation and enhanced vascularization induced by the SIM-loaded fibrous membranes.This study proposed an effective strategy to prepare a dual-loaded core-shell fibrous mem-brane for guided vascularized bone tissue regeneration.
文献关键词：
中图分类号：
作者姓名：
Chang Liu;Dan Deng;Jing Gao;Shue Jin;Yi Zuo;Yubao Li;Jidong Li
作者机构：
Research Center for Nano-Biomaterials,Analytical&Testing Center,Sichuan University,Chengdu 610064,China
文献出处：
引用格式：
[1]Chang Liu;Dan Deng;Jing Gao;Shue Jin;Yi Zuo;Yubao Li;Jidong Li-.Construction and Properties of Simvastatin and Calcium Phosphate Dual-Loaded Coaxial Fibrous Membranes with Osteogenic and Angiogenic Functions)[J].仿生工程学报（英文版）,2022(06):1645-1657
A类：
Angiogenic
B类：
Construction,Properties,Simvastatin,Calcium,Phosphate,Dual,Loaded,Coaxial,Fibrous,Membranes,Osteogenic,Functions,ideal,Guided,Bone,Regeneration,GBR,required,have,good,biocompatibility,space,maintenance,ability,appropriate,degradation,preferably,can,regeneration,vascularized,bone,tissue,In,this,study,SIM,calcium,CaP,were,encapsulated,Polycaprolactone,PCL,Chitosan,CS,core,shell,structural,fibrous,membranes,via,coaxial,electrospinning,technology,results,showed,that,loaded,structure,could,sustainably,release,drug,more,than,two,months,upregulate,angiogenic,marker,Mesenchymal,Stem,Cells,BMSCs,Adding,certain,amount,layer,provided,sites,mineralization,synergistic,promote,osteogenic,differentiation,vitro,intramuscular,implantation,experiments,rabbits,suggested,normal,early,inflammation,enhanced,vascularization,induced,by,This,proposed,effective,strategy,prepare,dual,guided
AB值：
0.67235
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
