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Chao-Nan Fan;Bo-Liang Fang;Heng-Miao Gao;Ru-Bo Li;Guo-Yun Su;Yi-Yang Mao;Yu-Shan He;Yue Wang;Xiao-He Zhou;Liang-Ming Cai;Ye-Qing wang;Jennifer A.Blumenthal;Su-Yun Qian - Pediatric Intensive Care Unit,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,No.56 Nan-Li-Shi Road,Beijing 100045,China;Division of Critical Care Medicine/Bader 6,Department of Anesthesiology,Critical Care and Pain Medicine,Boston Children's Hospital and Harvard Medical School,300 Longwood Avenue,Boston,MA 02115,USA

Eman R.Youness;Sherien M.El-Daly;Hanaa Reyad Abdallah;Hala T.El-Bassyouni;Hisham Megahed;Azzah A.Khedr;Marwa Elhady;Walaa Alsharany Abuelhamd - Medical Biochemistry Department,Medical Research Division,National Research Centre,Giza,Egypt;Biological Anthropology Department,Medical Research Division,National Research Centre,Giza,Egypt;Clinical Genetics Department,Human Genetics and Genome Research Division,National Research Centre,El-Tahrir Street,PO:12622,Giza,Egypt;Human Cytogenetics Department,Human Genetics and Genome Research Division,National Research Centre,Giza,Egypt;Pediatric Department,Faculty of Medicine for Girls,Al-Azhar University,Cairo,Egypt;Department of Pediatrics,Faculty of Medicine,Cairo University,Cairo,Egypt

Char Leung;Luisamanda Selle;Karina Mary de Paiva;Patricia Haas - School of Clinical Medicine,Addenbrooke's Hospital,University of Cambridge,Hills Road,Cambridge CB2 0QQ,UK;Department of Speech,Language and Hearing Sciences,Federal University of Santa Catarina,Florianópolis,Brazil

Xue Wang;Bin Zhang - Department of Dermatology,National Center for Children's Health,Beijing Children's Hospital,Capital Medical University,No.56 Nanlishi Road,Xi Cheng District,Beijing 100045,China;Affiliated Children's Hospital,Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,China

Yi He;Wanyanhan Jiang;Jia-Qiang Liao;Lin Jing;Jia Li;Lian Yang - HEOA Group,School of Public Health,Chengdu University of Traditional Chinese Medicine,No.1166 Liutai Road,Chengdu 611137,China;HEOA Group,West China School of Public Health,Sichuan University,No.17 People's South Road,Wuhou District,Chengdu 610041,China;HEOA Group,School of Management,Chengdu University of Traditional Chinese Medicine,No.1166 Liutai Road,Chengdu 611137,China

Hussein Zaitoon;Shaden Hanna;Ellen Bamberger - Department of Pediatrics,Bnai Zion Medical Center,The Ruth and Bruce Rappaport Faculty of Medicine,Technion-Israel Institute of Technology,47 Golomb St.,31048 Haifa,Israel;The Ruth and Bruce Rappaport Faculty of Medicine,Technion-Israel Institute of Technology,Haifa,Israel

Zakaria Barsoum - Consultant Paediatrician,South West Acute Hospital-Paediatric Department,124 Irvinestown Rd,Enniskillen,BT 74 6DN,Northern Ireland

Silvia Maya-Enero;Montserrat Fàbregas-Mitjans;Rosa Maria Llufriu-Marquès;Júlia Candel-Pau;Jordi Garcia-Garcia;María ángeles López-Vílchez - Department of Neonatology,Service of Pediatrics,Hospital del Mar,Parc de Salut Mar,Universitat Pompeu Fabra,Passeig Marítim 25-29,08003 Barcelona,Spain

Wen-Jia Zhao;Jiang-Hong Deng;Cai-Feng Li - Department of Rheumatology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,No.56,Nan Li Shi Road,Beijing 100045,China

Carolina Valderas;Gastón Méndez;Alejandra Echeverría;Nelson Suarez;Katherin Julio;Francisca Sandoval - Department of Neurology,Hospital Dr.Exequiel González Cortés,Gran Avenida José Miguel Carrera 3300,8900085 Santiago,Región Metropolitana,Chile