典型文献
Applications of mPCR testing reduced initial antibiotic use and duration of mechanical ventilation in virus-infected children with severe community-acquired pneumonia admitted to the PICU
文献摘要：
Community-acquired pneumonia(CAP)remains the leading cause of morbidity and mortality among children worldwide.It is critical for these patients to select and timely initiate appropriate empirical antimicrobial therapy against the causative pathogens[1].However,conventional pathogen-detecting methods,such as culture and serology,have no prospect of altering empiric therapy owing to their time delay in obtaining results and to their lower detection rates[2].Recent advances in molecular diagnostic assays,such as multiplex polymerase chain reaction PCR(mPCR)methods,have been used to detect multiple pathogens in CAP simul-taneously within two hours and have dramatically improved the ability to diagnose respiratory pathogens[3].However,whether this molecular diagnosis method can reduce the use of antibiotics and can improve prognosis in severe CAP children,especially those less than 5 years old,remains to be explored.
文献关键词：
中图分类号：
作者姓名：
Chao-Nan Fan;Bo-Liang Fang;Heng-Miao Gao;Ru-Bo Li;Guo-Yun Su;Yi-Yang Mao;Yu-Shan He;Yue Wang;Xiao-He Zhou;Liang-Ming Cai;Ye-Qing wang;Jennifer A.Blumenthal;Su-Yun Qian
作者机构：
Pediatric Intensive Care Unit,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,No.56 Nan-Li-Shi Road,Beijing 100045,China;Division of Critical Care Medicine/Bader 6,Department of Anesthesiology,Critical Care and Pain Medicine,Boston Children's Hospital and Harvard Medical School,300 Longwood Avenue,Boston,MA 02115,USA
文献出处：
引用格式：
[1]Chao-Nan Fan;Bo-Liang Fang;Heng-Miao Gao;Ru-Bo Li;Guo-Yun Su;Yi-Yang Mao;Yu-Shan He;Yue Wang;Xiao-He Zhou;Liang-Ming Cai;Ye-Qing wang;Jennifer A.Blumenthal;Su-Yun Qian-.Applications of mPCR testing reduced initial antibiotic use and duration of mechanical ventilation in virus-infected children with severe community-acquired pneumonia admitted to the PICU)[J].世界儿科杂志（英文版）,2022(06):449-452
A类：
mPCR,serology,empiric
B类：
Applications,testing,reduced,initial,duration,mechanical,ventilation,virus,infected,children,severe,community,acquired,pneumonia,admitted,PICU,Community,CAP,remains,leading,cause,morbidity,mortality,among,worldwide,It,critical,these,patients,select,timely,initiate,appropriate,empirical,antimicrobial,therapy,against,causative,pathogens,However,conventional,detecting,methods,such,culture,have,prospect,altering,owing,their,delay,obtaining,results,lower,detection,rates,Recent,advances,molecular,diagnostic,assays,multiplex,polymerase,chain,reaction,been,used,simul,taneously,within,two,hours,dramatically,improved,ability,diagnose,respiratory,whether,this,diagnosis,can,antibiotics,prognosis,especially,those,less,than,years,old,explored
AB值：
0.631131
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