Background Neonatal pain may affect long-term neurodevelopment and must be treated.Frenotomy is a painful procedure wherein a common strategy to relieve pain(sucking)cannot be used because the technique is performed on the tongue.Lavender essential oil(LEO)has sedative and antispasmodic properties and has been successfully used to treat pain during heel puncture and vaccination.Our aim was to demonstrate if the use of inhaled LEO is effective in reducing pain during frenotomy in healthy,full-term neonates.Methods We conducted a randomized clinical trial in neonates who underwent a frenotomy between August 2020 and April 2021.We assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and Neonatal Infant Pain Scale(NIPS)score.Patients with type 3 tongue tie were randomized into the"experimental group"and"control group".In both groups,we performed swaddling,administered oral sucrose,and let the newborn suck for two minutes.In the experimental group,we also placed a gauze pad with one drop of LEO under the neonate's nose for two minutes prior to and during the frenotomy.Results We enrolled 142 patients(71 per group).The experimental group showed significantly lower NIPS scores(1.88 vs 2.92)and cried almost half the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control group,we observed no side effects in either of the groups.Conclusions We observed a significant decrease in crying time and lower NIPS scores in the neonates who received inhaled LEO and underwent a frenotomy for type 3 tongue-ties.Thus,we recommend using inhaled LEO during neonatal frenotomies.

Silvia Maya-Enero;Montserrat Fàbregas-Mitjans;Rosa Maria Llufriu-Marquès;Júlia Candel-Pau;Jordi Garcia-Garcia;María ángeles López-Vílchez

Department of Neonatology,Service of Pediatrics,Hospital del Mar,Parc de Salut Mar,Universitat Pompeu Fabra,Passeig Marítim 25-29,08003 Barcelona,Spain

世界儿科杂志（英文版）

[1]Silvia Maya-Enero;Montserrat Fàbregas-Mitjans;Rosa Maria Llufriu-Marquès;Júlia Candel-Pau;Jordi Garcia-Garcia;María ángeles López-Vílchez-.Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates:a randomized clinical trial)[J].世界儿科杂志（英文版）,2022(06):398-403

lavender,frenotomy,Frenotomy,Lavender,antispasmodic,swaddling,suck,cried,frenotomies

Analgesic,inhaled,essential,oil,healthy,neonates,randomized,clinical,trial,Background,Neonatal,may,affect,long,term,neurodevelopment,must,treated,painful,procedure,wherein,common,strategy,relieve,sucking,cannot,used,because,technique,performed,tongue,LEO,has,sedative,properties,been,successfully,during,heel,puncture,vaccination,Our,aim,was,demonstrate,effective,reducing,Methods,We,conducted,who,underwent,between,August,April,assessed,using,pre,post,heart,oxygen,saturation,crying,Infant,Pain,Scale,NIPS,Patients,type,were,into,experimental,control,both,groups,administered,oral,sucrose,let,newborn,two,minutes,also,placed,gauze,pad,one,drop,nose,prior,Results,enrolled,patients,showed,significantly,lower,scores,almost,half,amount,seconds,Comparing,observed,side,effects,either,Conclusions,decrease,received,Thus,recommend,neonatal

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