典型文献
The double faced role of xanthine oxidoreductase in cancer
文献摘要：
Xanthine oxidoreductase(XOR)is a critical,rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid.It also produces reactive oxygen species(ROS)during the catalytic process.The enzyme is generally recognized as a drug target for the therapy of gout and hyperuricemia.The catalytic products uric acid and ROS act as antioxidants or oxidants,respectively,and are involved in pro/anti-inflammatory actions,which are associated with various disease manifestations,including metabolic syndrome,ischemia reperfusion injury,cardiovascular disorders,and cancer.Recently,extensive efforts have been devoted to understanding the paradoxical roles of XOR in tumor promotion.Here,we summarize the expression of XOR in different types of cancer and decipher the dual roles of XOR in cancer by its enzymatic or nonenzymatic activity to provide an updated understanding of the mechanistic function of XOR in cancer.We also discuss the potential to modulate XOR in cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Man-man Chen;Ling-hua Meng
作者机构：
Division of Anti-tumor Pharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Uniiversity of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Man-man Chen;Ling-hua Meng-.The double faced role of xanthine oxidoreductase in cancer)[J].中国药理学报（英文版）,2022(07):1623-1632
A类：
B类：
double,faced,oxidoreductase,cancer,Xanthine,XOR,critical,rate,limiting,enzyme,that,controls,last,two,steps,purine,catabolism,by,converting,hypoxanthine,acid,It,also,produces,reactive,oxygen,species,ROS,during,catalytic,process,generally,recognized,drug,target,therapy,gout,hyperuricemia,products,antioxidants,respectively,are,involved,inflammatory,actions,which,associated,various,disease,manifestations,including,metabolic,syndrome,ischemia,reperfusion,injury,cardiovascular,disorders,Recently,extensive,efforts,have,been,devoted,understanding,paradoxical,roles,tumor,promotion,Here,we,summarize,expression,different,types,decipher,dual,its,nonenzymatic,activity,provide,updated,mechanistic,function,We,discuss,potential,modulate
AB值：
0.60696
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
