典型文献
The biogenesis, function and clinical significance of circular RNAs in breast cancer
文献摘要：
Circular RNAs (circRNAs) are noncoding RNAs that form covalently closed loop structures. CircRNAs are dysregulated in cancer and play key roles in tumorigenesis, diagnosis, and tumor therapy. CircRNAs function as competing endogenous RNAs or microRNA sponges that regulate transcription and splicing, binding to proteins, and translation. CircRNAs may serve as novel biomarkers for cancer diagnosis, and they show potential as therapeutic targets in cancers including breast cancer (BC). In women, BC is the most common malignant tumor worldwide and the second leading cause of cancer death. Although evidence indicates that circRNAs play a critical role in BC, the mechanisms regulating the function of circRNAs in BC remain poorly understood. Here, we provide literature review aiming to clarify the role of circRNAs in BC and summarize the latest research. We provide a systematic overview of the biogenesis and biological functions of circRNAs, elaborate on the functional roles of circRNAs in BC, and highlight the value of circRNAs as diagnostic and therapeutic targets in BC.
文献关键词：
中图分类号：
作者姓名：
Yan Zeng;Yutian Zou;Guanfeng Gao;Shaoquan Zheng;Song Wu;Xiaoming Xie;Hailin Tang
作者机构：
Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China
文献出处：
引用格式：
[1]Yan Zeng;Yutian Zou;Guanfeng Gao;Shaoquan Zheng;Song Wu;Xiaoming Xie;Hailin Tang-.The biogenesis, function and clinical significance of circular RNAs in breast cancer)[J].癌症生物学与医学（英文版）,2022(01):14-29
A类：
CircRNAs
B类：
biogenesis,clinical,significance,circular,breast,Circular,circRNAs,are,noncoding,that,form,covalently,closed,loop,structures,dysregulated,play,key,roles,tumorigenesis,diagnosis,therapy,competing,endogenous,microRNA,sponges,transcription,splicing,binding,proteins,translation,may,serve,novel,biomarkers,they,show,potential,therapeutic,targets,cancers,including,BC,In,women,most,common,malignant,worldwide,second,leading,cause,death,Although,evidence,indicates,critical,mechanisms,regulating,remain,poorly,understood,Here,we,provide,literature,review,aiming,clarify,summarize,latest,research,We,systematic,overview,biological,functions,elaborate,functional,highlight,value,diagnostic
AB值：
0.554882
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