典型文献
A near-infrared plasma membrane-specific AIE probe for fluorescence lifetime imaging of phagocytosis
文献摘要：
Phagocytosis is a biological process that plays a key role in host defense and tissue homeostasis.Efficient approaches for real-time imaging of phagocytosis are highly desired but limited.Herein,an AIE-active near-infrared fluorescent probe,named TBTCP,was developed for fluorescence lifetime imaging of phagocytosis.TBTCP could selectively label the cell plasma membrane with fast staining,wash-free process,high signal-to-background ratio,and excellent photostability.Cellular mem-brane statuses under different osmolarities as well as macrophage phagocytosis of bacteria or large silica particles in early stages could be reported by the fluorescence lifetime changes of TBTCP.Compared with current fluorescence imaging methods,which target the bioenvironmental changes in the late phagocytosis stage,this approach detects the changes in the cell membrane,thus giving a faster response to phagocytosis.This article provides a functional tool to report the phagocytic dynamics of macro-phages which may greatly contribute to the studies of phagocytic function-related diseases.
文献关键词：
中图分类号：
作者姓名：
Ming-Yu Wu;Jong-Kai Leung;Chuen Kam;Tsu Yu Chou;Jia-Li Wang;Xueqian Zhao;Shun Feng;Sijie Chen
作者机构：
Ming Wai Lau Centre for Reparative Medicine,Karolinska Institutet,Hong Kong,China;Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China
文献出处：
引用格式：
[1]Ming-Yu Wu;Jong-Kai Leung;Chuen Kam;Tsu Yu Chou;Jia-Li Wang;Xueqian Zhao;Shun Feng;Sijie Chen-.A near-infrared plasma membrane-specific AIE probe for fluorescence lifetime imaging of phagocytosis)[J].中国科学:化学（英文版）,2022(05):979-988
A类：
Phagocytosis,TBTCP,statuses,osmolarities,bioenvironmental
B类：
near,infrared,plasma,membrane,specific,AIE,probe,fluorescence,lifetime,imaging,phagocytosis,biological,process,that,plays,key,role,host,defense,tissue,homeostasis,Efficient,approaches,real,highly,desired,limited,Herein,active,fluorescent,named,developed,could,selectively,label,staining,wash,free,signal,background,ratio,excellent,photostability,Cellular,under,different,well,macrophage,bacteria,large,silica,particles,early,stages,reported,by,changes,Compared,current,methods,which,target,this,detects,thus,giving,faster,response,This,provides,functional,tool,phagocytic,dynamics,phages,may,greatly,contribute,studies,related,diseases
AB值：
0.511971
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
