典型文献
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
文献摘要：
Traditional medicine has provided a basis for health care and disease treatment to Chinese people for millennia,and herbal medicines are regulated as drug products in China.Chinese herbal medicines have two features.They normally possess very complex chemical composition.This makes the identification of the constituents that are together responsible for the therapeutic action of an herbal medicine challenging,because how to select compounds from an herbal medicine for pharmacodynamic study has been a big hurdle in such identification efforts.To this end,a multi-compound pharmacokinetic approach was established to identify potentially important compounds(bioavailable at the action loci with significant exposure levels after dosing an herbal medicine)and to characterize their pharmacokinetics and disposition.Another feature of Chinese herbal medicines is their typical use as or in combination therapies.Coadministration of complex natural products and conventional synthetic drugs is prevalent worldwide,even though it remains very controversial.Natural product-drug interactions have raised wide concerns about reduced drug efficacy or safety.However,growing evidence shows that incorporating Chinese herbal medicines into synthetic drug-based therapies delivers benefits in the treatment of many multifactorial diseases.To address this issue,a drug-combination pharmacokinetic approach was established to assess drug-drug interaction potential of herbal medicines and degree of pharmacokinetic compatibility for multi-herb combination and herbal medicine-synthetic drug combination therapies.In this review we describe the methodology,techniques,requirements,and applications of multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines and to discuss further development for these two types of pharmacokinetic research.
文献关键词：
中图分类号：
作者姓名：
Chuan Li;Wei-wei Jia;Jun-ling Yang;Chen Cheng;Olajide E.Olaleye
作者机构：
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China
文献出处：
引用格式：
[1]Chuan Li;Wei-wei Jia;Jun-ling Yang;Chen Cheng;Olajide E.Olaleye-.Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines)[J].中国药理学报（英文版）,2022(12):3080-3095
A类：
Coadministration
B类：
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AB值：
0.48836
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