典型文献
nr0b1(DAX1)loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation
文献摘要：
The nuclear receptor DAX-1,encoded by the NR0B1 gene,is presented in the hypothalamic tissues in humans and other vertebrates.Human patients with NR0B1 mutations often have hypothalamic-pituitary defects,but the involvement of NR0B1 in hypothalamic development and function is not well under-stood.Here,we report the disruption of the nr0b1 gene in zebrafish causes abnormal expression of go-nadotropins,a reduction in fertilization rate,and an increase in postfasting food intake,which are indicators of abnormal hypothalamic functions.We find that loss of nr0b1 increases the number of prodynorphin(ppdyn)-expressing neurons but decreases the number of pro-opiomelanocortin(pomcb)-expressing neu-rons in the zebrafish hypothalamic arcuate region(ARC).Further examination reveals that the proliferation of progenitor cells is reduced in the hypothalamus of nr0b1 mutant embryos accompanying the decreased expression of genes in the Notch signaling pathway.Additionally,the inhibition of Notch signaling in wild-type embryos increases the number of pdyn neurons,mimicking the nr0b1 mutant phenotype.In contrast,ectopic activation of Notch signaling in nr0b1 mutant embryos decreases the number of pdyn neurons.Taken together,our results suggest that nr0b1 regulates neural progenitor proliferation and maintenance to ensure normal hypothalamic neuron development.
文献关键词：
中图分类号：
作者姓名：
Wei Zhang;Yan Li;Sijie Chen;Cuizhen Zhang;Lili Chen;Gang Peng
作者机构：
State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200032,China;Department of Endocrinology,Huashan Hospital,Fudan University,Shanghai 200040,China
文献出处：
引用格式：
[1]Wei Zhang;Yan Li;Sijie Chen;Cuizhen Zhang;Lili Chen;Gang Peng-.nr0b1(DAX1)loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation)[J].遗传学报,2022(03):217-229
A类：
nr0b1,DAX1,nadotropins,postfasting,prodynorphin,ppdyn,pomcb,pdyn
B类：
loss,zebrafish,causes,hypothalamic,defects,via,abnormal,progenitor,proliferation,differentiation,nuclear,receptor,encoded,by,NR0B1,presented,tissues,humans,other,vertebrates,Human,patients,mutations,often,have,pituitary,but,involvement,development,well,under,stood,Here,report,disruption,expression,go,reduction,fertilization,food,intake,which,are,indicators,functions,We,find,that,increases,number,expressing,neurons,decreases,opiomelanocortin,arcuate,region,ARC,Further,examination,reveals,cells,reduced,hypothalamus,mutant,embryos,accompanying,decreased,genes,Notch,signaling,pathway,Additionally,inhibition,wild,mimicking,phenotype,In,contrast,ectopic,activation,Taken,together,our,results,suggest,regulates,neural,maintenance,ensure
AB值：
0.444472
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