典型文献
Exploring the Alzheimer 's disease neuroepigenome: recent advances and future trends
文献摘要：
Exploring the Alzheimer's disease neuroepigenome: recent advances and future trends: Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmarks of AD, such as amyloid-β (Aβ) and tau pathologies, have finally been understood. But these milestone discoveries still failed to help us find a cure. In recent years, based on advances in genomics, researchers have discovered more than 20 AD-associated alleles. Three of these alleles can cause autosomal dominant AD: amyloid precursor protein and presenilin 1/2 genes. The rest of these alleles can increase the risk to AD, such as the apolipoprotein E gene. These risk loci implicate Aβ, tau, immunity, and lipid processing, which have helped us accurately understand the complex changes in AD patients' molecular networks.
文献关键词：
中图分类号：
作者姓名：
Haolin Zhang
作者机构：
Department of Biology,Drexel University,Philadelphia,PA,USA
文献出处：
引用格式：
[1]Haolin Zhang-.Exploring the Alzheimer 's disease neuroepigenome: recent advances and future trends)[J].中国神经再生研究（英文版）,2022(02):325-327
A类：
neuroepigenome
B类：
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AB值：
0.61852
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