典型文献
Toward future adaptive deep brain stimulation for Parkinson's disease: the novel biomarker — narrowband gamma oscillation
文献摘要：
Parkinson's disease (PD) is one of the most common neurodegenerative diseases, affecting individuals especially over 60 years of age. In the next three decades, more than 12 million people will suffer from PD worldwide (Rocca, 2018). The characteristic symptoms of PD begin as a movement disorder including bradykinesia, resting tremor, rigidity, and postural instability. Among these symptoms, bradykinesia is considered to be the major feature in diagnosing PD. At early stages, the motor symptoms of PD can be traced back to the loss of dopaminergic neurons of the substantia nigra (Armstrong and Okun, 2020). The other known neuropathological hallmark of PD is the intracellular inclusions containing the aggregates of a-synuclein (Armstrong and Okun, 2020). Nevertheless, consensus exists that the dysfunction of the interconnected neural networks plays a fundamental role in the presence of clinical symptoms given the anatomical and functional interactions within the brain. The current most prevalent clinical treatment involves substituting dopamine with medication and suppressing pathological neural activity via deep brain stimulation (DBS).
文献关键词：
中图分类号：
作者姓名：
Hao Ding
作者机构：
Movement Disorders and Neurostimulation,Biomedical Statistics and Multimodal SignalProcessing,Department of Neurology,JohannesGutenberg University,Mainz,Germany
文献出处：
引用格式：
[1]Hao Ding-.Toward future adaptive deep brain stimulation for Parkinson's disease: the novel biomarker — narrowband gamma oscillation)[J].中国神经再生研究（英文版）,2022(03):557-558
A类：
Rocca,bradykinesia,Okun,neuropathological
B类：
Toward,future,adaptive,deep,brain,stimulation,Parkinson,novel,biomarker,narrowband,gamma,oscillation,one,most,common,neurodegenerative,diseases,affecting,individuals,especially,over,years,In,next,three,decades,more,than,million,people,will,suffer,from,worldwide,characteristic,symptoms,begin,movement,disorder,including,resting,tremor,rigidity,postural,instability,Among,these,considered,major,feature,diagnosing,At,early,stages,motor,can,traced,back,loss,dopaminergic,neurons,substantia,nigra,Armstrong,other,known,hallmark,intracellular,inclusions,containing,aggregates,synuclein,Nevertheless,consensus,exists,that,dysfunction,interconnected,neural,networks,plays,fundamental,role,presence,clinical,given,anatomical,functional,interactions,within,current,prevalent,treatment,involves,substituting,medication,suppressing,activity,via,DBS
AB值：
0.663478
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
