典型文献
Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles
文献摘要：
The prevalence of Parkinson's disease (PD) is rapidly increasing, and more than 12 million people are expected to suffer from PD by 2040. PD is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies, which include both misfolded α-synuclein (α-syn) protein and a multitude of fragmented membranes, organelles, and vesicles (Shahmoradian et al., 2019; Lashuel, 2020). No reliable biomarkers that can predict the onset of PD in its prodromal phase or could assess disease progression are currently available. α-Syn plays a pivotal role in the pathogenesis of PD and is present in peripheral tissues and biofluids; this led to the investigation of α-syn as a possible PD biomarker.
文献关键词：
中图分类号：
作者姓名：
Cristina Agliardi;Franca R.Guerini;Mario Meloni;Mario Clerici
作者机构：
IRCCS Fondazione Don Carlo Gnocchi,Milan,Italy;Department of Pathophysiology and Transplantation,University of Milan,Milan,Italy
文献出处：
引用格式：
[1]Cristina Agliardi;Franca R.Guerini;Mario Meloni;Mario Clerici-.Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles)[J].中国神经再生研究（英文版）,2022(07):1503-1504
A类：
extracelluar,invalidating,Shahmoradian,Lashuel,prodromal
B类：
Alpha,synuclein,Parkinson,disease,focus,neural,derived,vesicles,prevalence,rapidly,increasing,more,than,million,people,are,expected,suffer,from,by,highly,neurodegenerative,condition,that,arises,progressive,degeneration,dopaminergic,neurons,substantia,nigra,pars,compacta,main,cause,such,formation,cytoplasmic,inclusions,known,Lewy,bodies,which,include,both,misfolded,protein,multitude,fragmented,membranes,organelles,No,reliable,biomarkers,can,predict,onset,its,phase,could,assess,progression,currently,available,Syn,plays,pivotal,role,pathogenesis,present,peripheral,tissues,biofluids,this,led,investigation,possible
AB值：
0.636865
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
