典型文献
Designing nanocarriers to overcome the limitations in conventional drug administration for Parkinson's disease
文献摘要：
Neurodegenerative diseases (NDs) have become one of the leading causes of death and disability worldwide, and cause enormous pain and suffering for both patients and their families. Some of the most common NDs include Alzheimer's disease, Parkinson's disease (PD) and Huntington's disease, among others (Feng, 2020). PD is a widespread neurodegenerative disease that affects more than 10 million people worldwide (No author listed, 2021). The direct cause of the disease is unknown, but it is characterized by the selective degeneration of dopaminergic neurons in the midbrain in the substantia nigra. This leads to the depletion of dopamine (3,4-dihydroxyphenethylamine, DA) in the striatum of patients, in addition to the existence of abnormal α-synuclein in nerve cells and the development of toxic protein aggregates in neurons called Lewy bodies, which causes muscle stiffness, slowness of movements and tremors. It is believed that a combination of genetic and environmental factors may be the cause of PD, but the exact reason for the disease is not yet fully understood.
文献关键词：
中图分类号：
作者姓名：
Rafael A.García-Mu?oz;Joseph McConnell;Victoria Morales;Raul Sanz
作者机构：
Department of Chemical and Environmental Technology,Rey Juan Carlos University,Madrid,Spain;Department of Chemical&Process Engineering,University of Strathclyde,Glasgow,UK
文献出处：
引用格式：
[1]Rafael A.García-Mu?oz;Joseph McConnell;Victoria Morales;Raul Sanz-.Designing nanocarriers to overcome the limitations in conventional drug administration for Parkinson's disease)[J].中国神经再生研究（英文版）,2022(08):1743-1744
A类：
dihydroxyphenethylamine,slowness
B类：
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AB值：
0.67627
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
