典型文献
The role of lysosomes in alpha-synucleinopathies: a focus on glial cells
文献摘要：
Lysosomes are the major degradative compartments within eukaryotic cells. Besides their role in the degradation and recycling of intra- and extracellular molecules, they further mediate important biological processes, such as immune signaling and perpetuation of nutrient- and energy homeostasis. Impairment of lysosomal function triggers the accumulation of catabolic products within the organelle resulting in lysosomal storage disorders (LSDs). Interestingly, clinical, molecular, and genetic studies further indicate a strong link between lysosomal dysfunction and neurodegenerative disorders, including Parkinson's disease (PD). Because of the association of lysosomal dysfunction and protein aggregation of α-synuclein (α-Syn) in PD or multiple system atrophy (MSA), the role of lysosomal pathways has been a matter of recent studies, mostly focusing on neuronal cells. Although it is known that glial cells play an important role in disease pathology of PD and MSA, only few studies on the lysosomal pathways, within glial cells have been carried out. Hence, a better understanding of lysosomal function in glia is needed to elucidate disease pathogenesis and to search for novel therapeutic approaches.
文献关键词：
中图分类号：
作者姓名：
Denise Balta;Friederike Zunke
作者机构：
Department of Molecular Neurology,University Hospital Erlangen,Friedrich-Alexander-Universit?t Erlangen-Nürnberg,Erlangen,Germany
文献出处：
引用格式：
[1]Denise Balta;Friederike Zunke-.The role of lysosomes in alpha-synucleinopathies: a focus on glial cells)[J].中国神经再生研究（英文版）,2022(07):1486-1488
A类：
Lysosomes,perpetuation,LSDs
B类：
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AB值：
0.597727
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
