典型文献
Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex
文献摘要：
Nuclear pore complex(NPC)mediates nucleocytoplasmic shuttling.Here we present single-particle cryo-electron microscopy structure of the inner ring(IR)subunit from the Xenopus laevis NPC at an average resolution of 4.2 ?.A homo-dimer of Nup205 resides at the center of the IR subunit,flanked by two molecules of Nup188.Four molecules of Nup93 each places an extended helix into the axial groove of Nup205 or Nup188,together constituting the central scaffold.The channel nucleoporin hetero-trimer of Nup62/58/54 is anchored on the central scaffold.Six Nup155 molecules interact with the central scaffold and together with the NDC1-ALADIN hetero-dimers anchor the IR subunit to the nuclear envelope and to outer rings.The scarce inter-subunit contacts may allow sufficient latitude in conformation and diameter of the IR.Our structure reveals the molecular basis for the IR subunit assembly of a vertebrate NPC.
文献关键词：
中图分类号：
作者姓名：
Gaoxingyu Huang;Xiechao Zhan;Chao Zeng;Ke Liang;Xuechen Zhu;Yanyu Zhao;Pan Wang;Qifan Wang;Qiang Zhou;Qinghua Tao;Minhao Liu;Jianlin Lei;Chuangye Yan;Yigong Shi
作者机构：
Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou,Zhejiang,China;Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,Hangzhou,Zhejiang,China;Institute of Biology,Westlake Institute for Advanced Study,18 Shilongshan Road,Hangzhou,Zhejiang,China;Beijing Advanced Innovation Center for Structural Biology&Frontier Research Center for Biological Structure,Beijing,China;Tsinghua University-Peking University Joint Center for Life Sciences;School of Life Sciences,Tsinghua University,Beijing,China
文献出处：
引用格式：
[1]Gaoxingyu Huang;Xiechao Zhan;Chao Zeng;Ke Liang;Xuechen Zhu;Yanyu Zhao;Pan Wang;Qifan Wang;Qiang Zhou;Qinghua Tao;Minhao Liu;Jianlin Lei;Chuangye Yan;Yigong Shi-.Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex)[J].细胞研究（英文版）,2022(05):451-460
A类：
nucleocytoplasmic,Nup205,Nup188,Nup93,nucleoporin,Nup62,Nup155,NDC1,ALADIN
B类：
Cryo,EM,structure,inner,from,Xenopus,laevis,nuclear,pore,complex,Nuclear,NPC,mediates,shuttling,Here,we,present,single,particle,cryo,electron,microscopy,subunit,average,resolution,homo,resides,center,flanked,by,two,molecules,Four,each,places,extended,helix,into,axial,groove,together,constituting,central,scaffold,channel,hetero,trimer,anchored,Six,interact,dimers,envelope,outer,rings,scarce,contacts,may,allow,sufficient,latitude,conformation,diameter,Our,reveals,molecular,basis,assembly,vertebrate
AB值：
0.500928
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
