典型文献
Single-cell transcriptomic profiling of the hypothalamic median eminence during aging
文献摘要：
Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circu-lating molecules,leading to systemic and reproductive aging.However,the molecular and cellular features of ME aging remain largely unknown.Here,we describe the transcriptional landscape of young and middle-aged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with age.The transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cell-extrinsic factors highlight five molecular features of ME aging and also implicate several potentially drug-gable targets at cellular,signaling,and molecular levels.Importantly,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome.Together,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.
文献关键词：
中图分类号：
作者姓名：
Zhen-Hua Chen;Si Li;Mingrui Xu;Candace C.Liu;Hongying Ye;Ben Wang;Qing-Feng Wu
作者机构：
State Key Laboratory of Molecular Development Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100101,China;Department of Pathology,Stanford University School of Medicine,Stanford,CA 94305,USA;Department of Endocrinology and Metabolism,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Obstetrics and Gynecology,Baoding Second Central Hospital,Baoding,Hebei 072750,China;Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Beijing 100101,China;Chinese Institute for Brain Research,Beijing 102206,China;Beijing Children's Hospital,Capital Medical University,Beijing 100045,China
文献出处：
引用格式：
[1]Zhen-Hua Chen;Si Li;Mingrui Xu;Candace C.Liu;Hongying Ye;Ben Wang;Qing-Feng Wu-.Single-cell transcriptomic profiling of the hypothalamic median eminence during aging)[J].遗传学报,2022(06):523-536
A类：
gable,asynchronized
B类：
Single,transcriptomic,profiling,hypothalamic,median,eminence,during,aging,Aging,slow,progressive,natural,process,that,compromises,normal,functions,cells,tissues,organs,systems,ME,structural,gate,linking,neural,endocrine,may,impair,hormone,release,energy,homeostasis,central,sensing,circu,lating,molecules,leading,systemic,reproductive,However,molecular,cellular,features,remain,largely,unknown,Here,describe,transcriptional,landscape,young,middle,aged,mouse,single,resolution,revealing,common,specific,changes,intrinsic,programs,crosstalk,extrinsic,factors,highlight,five,also,implicate,several,potentially,drug,targets,signaling,levels,Importantly,our,results,suggest,vascular,leptomeningeal,among,diverse,types,drive,local,inflammation,senescence,via,unique,secretome,Together,study,uncovers,how,each,are,changed,by,which,will,facilitate,understanding,brain,provide,clues,efficient,anti,intervention,stage
AB值：
0.61845
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
