典型文献
Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases
文献摘要：
Age-dependent protein-conformational diseases (PCDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual. Recent evidence supports the notion that bacteria and bacterial products may be affecting the stability of these culprit host proteins and therefore influence disease progression and perhaps even its onset. Although specific culprit proteins are associated with each disease (e.g., Aβ in AD, α-synuclein in PD, and TDP-43 in ALS), bacteria found to affect these diseases do not seem to differentiate between these specific proteins but likely affect host proteostasis in general, leading to misfolding of metastable proteins encoded within the proteome.
文献关键词：
中图分类号：
作者姓名：
Daniel M.Czy?
作者机构：
Department of Microbiology and Cell Science,University of Florida,Gainesville,FL,USA
文献出处：
引用格式：
[1]Daniel M.Czy?-.Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases)[J].中国神经再生研究（英文版）,2022(10):2203-2204
A类：
proteostasis
B类：
Exploiting,Caenorhabditis,elegans,discover,human,gut,microbiota,mediated,intervention,strategies,conformational,diseases,Age,dependent,PCDs,such,Alzheimer,AD,Parkinson,amyotrophic,lateral,sclerosis,ALS,are,characterized,by,misfolding,aggregation,metastable,proteins,present,within,proteome,affected,individual,Recent,evidence,supports,notion,that,bacterial,products,may,affecting,stability,these,culprit,host,therefore,influence,progression,perhaps,even,its,onset,Although,specific,associated,each,synuclein,TDP,found,do,seem,differentiate,between,but,likely,general,leading,encoded
AB值：
0.627225
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
