典型文献
Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity
文献摘要：
Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke hyperglycemia is also present in a number of non-diabetic patients after acute ischemic stroke, presumably as a stress response. The aim of this review is to summarize the main effects of hyperglycemia when associated to ischemic injury in acute stroke patients, highlighting the clinical and neurological outcomes in these conditions and after the administration of the currently approved pharmacological treatment, i.e. insulin. The disappointing results of the clinical trials on insulin (including the hypoglycemic events) demand a change of strategy based on more focused therapies. Starting from the comprehensive evaluation of the physiopathological alterations occurring in the ischemic brain during hyperglycemic conditions, the effects of various classes of glucose-lowering drugs are reviewed, such as glucose-like peptide-1 receptor agonists, DPP-4 inhibitors and sodium glucose cotransporter 2 inhibitors, in the perspective of overcoming the up-to-date limitations and of evaluating the effectiveness of new potential therapeutic strategies.
文献关键词：
中图分类号：
作者姓名：
Federica Ferrari
作者机构：
Department of Biology and Biotechnology,Laboratory of Pharmacology and Molecular Medicine of Central Nervous System,University of Pavia,Via Ferrata,Pavia,Italy
文献出处：
引用格式：
[1]Federica Ferrari-.Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity)[J].中国神经再生研究（英文版）,2022(02):292-299
A类：
physiopathological
B类：
Hyperglycemia,acute,ischemic,stroke,therapeutic,complexity,Diabetes,mellitus,associated,chronic,hyperglycemia,enhance,risk,lead,worsened,clinical,increased,mortality,However,post,also,present,number,diabetic,patients,after,presumably,stress,response,aim,this,summarize,main,effects,when,injury,highlighting,neurological,outcomes,these,conditions,administration,currently,approved,pharmacological,treatment,insulin,disappointing,results,trials,including,hypoglycemic,events,demand,change,strategy,more,focused,therapies,Starting,from,comprehensive,evaluation,alterations,occurring,brain,during,hyperglycemic,various,classes,glucose,lowering,drugs,are,reviewed,such,like,peptide,receptor,agonists,DPP,inhibitors,sodium,cotransporter,perspective,overcoming,up,date,limitations,evaluating,effectiveness,new,potential,strategies
AB值：
0.632777
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
