典型文献
Construction and applications of DNA-based nanomaterials in cancer therapy
文献摘要：
As a biologically active macromolecule,deoxyribonucleic acid(DNA)has the advantages of sequence pro-grammability and structure controllability and can accurately transmit sequence information to specific biological functions.Facing the complex internal microenvironment and heterogeneity in tumor treat-ment,the construction and applications of DNA-based nanomaterials have become a focus point of re-search.In particular,the hybridization of DNA molecules with other materials endows DNA-based nano-materials with multiple functions such as targeting,stimulus responsiveness and regulations of biolog-ical activities,making DNA nanostructures great potential in the treatment of major human diseases.In this review,the construction and characteristics of DNA-based nanomaterials are introduced.Then,the functions and applications of DNA-based nanomaterials in the delivery of chemotherapy drugs and gene drugs,stimulus-responsive release and regulation of cell homeostasis are reviewed.Finally,the fu-ture development and challenges of DNA-based nanomaterials are prospected.We envision that DNA-based nanomaterials can enrich the nanomaterial system by rational design and synthesis and address the growing demands on biological and biomedical applications in the real world.
文献关键词：
中图分类号：
作者姓名：
Hedong Qi;Yuwei Xu;Pin Hu;Chi Yao;Dayong Yang
作者机构：
Frontiers Science Center for Synthetic Biology,Key Laboratory of Systems Bioengineering(MOE),School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China
文献出处：
引用格式：
[1]Hedong Qi;Yuwei Xu;Pin Hu;Chi Yao;Dayong Yang-.Construction and applications of DNA-based nanomaterials in cancer therapy)[J].中国化学快报（英文版）,2022(03):1131-1140
A类：
grammability
B类：
Construction,applications,nanomaterials,cancer,biologically,active,macromolecule,deoxyribonucleic,acid,has,advantages,sequence,controllability,accurately,transmit,information,specific,functions,Facing,complex,internal,microenvironment,heterogeneity,tumor,construction,have,become,focus,point,search,In,particular,hybridization,molecules,endows,multiple,such,targeting,stimulus,responsiveness,regulations,activities,making,nanostructures,great,potential,treatment,major,human,diseases,this,characteristics,are,introduced,Then,delivery,chemotherapy,drugs,release,cell,homeostasis,reviewed,Finally,development,challenges,prospected,We,envision,that,enrich,system,by,rational,design,synthesis,address,growing,demands,biomedical,real,world
AB值：
0.52885
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