典型文献
In vivo Toxicity Evaluation of a Nano-drug Delivery System Using a Caenorhabditis elegans Model System
文献摘要：
Drug carrier materials need to possess good biological safety.Presently,most biosafety evaluation studies use rodent animal models,including rats and rabbits.However,the cost of raising these animals is relatively high and the experimental period is long.Caenorhabditis elegans(C.elegans)presents an ideal toxicological evaluation model due to its simple structure,easy cultivation,short life cycle,and evolutionary conservation.In this paper,we used C.elegans to test the biological safety of our pH-responsive carrier system(FFPFF self-assembling into a nanosphere structure,FFPFF Nps),which was designed for anti-tumor drug delivery.Our results showed that exposure to high doses of FFPFF Nps did not have a significant impact on the survival rate,growth,development,movement,and reproduction of C.elegans.The preliminary evaluation of the overall biological model of C.elegans shows that FFPFF Nps has good biological safety and warrants further study.
文献关键词：
中图分类号：
作者姓名：
HAN Wenzhao;Li Hui;YU Xiaoxuan;KE Junfeng;GUO Feng;WANG Liping
作者机构：
Key Laboratory for Molecular Enzymology and Engineering,Ministry of Edu-cation,School of Life Sciences,Engineering Laboratory for AIDS Vaccine,Jilin Universtiy,Changchun 130012,P.R.China
文献出处：
引用格式：
[1]HAN Wenzhao;Li Hui;YU Xiaoxuan;KE Junfeng;GUO Feng;WANG Liping-.In vivo Toxicity Evaluation of a Nano-drug Delivery System Using a Caenorhabditis elegans Model System)[J].高等学校化学研究（英文版）,2022(04):1018-1024
A类：
FFPFF,Nps
B类：
In,vivo,Toxicity,Evaluation,Nano,drug,Delivery,System,Using,Caenorhabditis,elegans,Model,Drug,carrier,materials,need,possess,good,biological,Presently,most,biosafety,evaluation,studies,rodent,models,including,rats,rabbits,However,cost,raising,these,animals,relatively,high,experimental,period,long,presents,ideal,toxicological,due,simple,structure,easy,cultivation,short,life,cycle,evolutionary,conservation,this,paper,used,test,our,responsive,system,self,assembling,into,nanosphere,which,was,designed,anti,tumor,delivery,Our,results,showed,that,exposure,doses,did,not,have,significant,impact,survival,rate,growth,development,movement,reproduction,preliminary,overall,shows,has,warrants,further,study
AB值：
0.630344
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
