典型文献
Stable isotope labeling of nanomaterials for biosafety evaluation and drug development
文献摘要：
Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of nanomaterials.Due to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the organisms.The isotopic trac-ers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical properties.In this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological effects.The skeleton labeling protocols of carbon nano-materials and metal/metal oxide nanoparticles were introduced.The advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for nanomaterials.The quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety data.The benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and safety.Finally,the challenges and future perspec-tives of stable isotope labeling in nanoscience and nanotechnology were discussed.
文献关键词：
中图分类号：
作者姓名：
Xue-Ling Chang;Lingyun Chen;Boning Liu;Sheng-Tao Yang;Haifang Wang;Aoneng Cao;Chunying Chen
作者机构：
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission,School of Chemistry and Environment,Southwest Minzu University,Chengdu 610041,China;Institute of Nanochemistry and Nanobiology,Shanghai University,Shanghai 200444,China;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,and University of Chinese Academy of Sciences,Beijing 100190,China
文献出处：
引用格式：
[1]Xue-Ling Chang;Lingyun Chen;Boning Liu;Sheng-Tao Yang;Haifang Wang;Aoneng Cao;Chunying Chen-.Stable isotope labeling of nanomaterials for biosafety evaluation and drug development)[J].中国化学快报（英文版）,2022(07):3303-3314
A类：
nanosafety
B类：
Stable,isotope,labeling,nanomaterials,biosafety,drug,development,Quantitative,information,such,environmental,migration,absorption,biodistribution,biotransformation,elimination,fundamental,essential,evaluations,Due,complexity,biological,systems,challenging,quantitative,approaches,tools,that,could,characterize,intrinsic,behaviors,organisms,isotopic,trac,are,ideal,candidates,tune,physical,properties,while,preserving,their,chemical,In,this,review,summarized,stable,methods,evaluating,effects,skeleton,protocols,carbon,metal,oxide,nanoparticles,were,introduced,disadvantages,discussed,comparison,other,was,along,data,benefits,nanomedicine,analyzed,targeting,persistent,accumulation,Finally,challenges,future,perspec,tives,nanoscience,nanotechnology
AB值：
0.535551
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