Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many bio-medical engineering and scientific applications,including drug delivery,electrophysiological recording and regula-tion of intracellular activities.Semi-implantable bioelec-tronics is currently a hot spot in biomedical engineering research area,because it not only meets the increasing technical demands for precise detection or regulation of biological activities,but also provides a desirable platform for externally incorporating complex functionalities and electronic integration.Although there is less definition and summary to distinguish it from the well-reviewed non-invasive bioelectronics and fully implantable bioelectronics,semi-implantable bioelectronics have emerged as highly unique technology to boost the development of biochips and smart wearable device.Here,we reviewed the recent progress in this field and raised the concept of"Semi-implantable bioelectronics",summarizing the principle and strategies of semi-implantable device for cell applications and in vivo applications,dis-cussing the typical methodologies to access to intracellular environment or in vivo environment,biosafety aspects and typical applica-tions.This review is meaningful for understanding in-depth the design principles,materials fabrication techniques,device integration processes,cell/tissue penetration methodologies,biosafety aspects,and applications strategies that are essential to the development of future minimally invasive bioelectronics.

Jiaru Fang;Shuang Huang;Fanmao Liu;Gen He;Xiangling Li;Xinshuo Huang;Hui-jiuan Chen;Xi Xie

State Key Laboratory of Optoelectronic Materials and Technologies,Guangdong Province Key Laboratory of Display Material and Technology,School of Electronics and Information Technology,Sun Yat-Sen University,Guangzhou 510006,People's Republic of China

纳微快报（英文）

[1]Jiaru Fang;Shuang Huang;Fanmao Liu;Gen He;Xiangling Li;Xinshuo Huang;Hui-jiuan Chen;Xi Xie-.Semi-Implantable Bioelectronics)[J].纳微快报（英文）,2022(07):354-408

bioelec,biochips,cussing

Semi,Implantable,Bioelectronics,Developing,techniques,effectively,real,monitor,regulate,interior,environment,biological,objects,significantly,important,many,engineering,scientific,applications,including,drug,delivery,electrophysiological,recording,intracellular,activities,implantable,currently,hot,spot,biomedical,research,area,because,not,only,meets,increasing,technical,demands,precise,detection,regulation,but,also,provides,desirable,platform,externally,incorporating,complex,functionalities,integration,Although,there,less,definition,summary,distinguish,from,well,reviewed,invasive,bioelectronics,fully,semi,have,emerged,highly,unique,technology,boost,development,smart,wearable,device,Here,recent,progress,this,field,raised,concept,summarizing,strategies,vivo,typical,methodologies,access,biosafety,aspects,This,meaningful,understanding,depth,design,principles,materials,fabrication,processes,tissue,penetration,that,essential,future,minimally

0.553872