典型文献
Caging-Decaging Strategies to Realize Spatiotemporal Control of DNAzyme Activity for Biosensing and Bioimaging
文献摘要：
DNAzymes with RNA-cleaving activity have been widely used as biosensing and bioimaging tools for detection of metal ions.Despite the achievements,DNAzyme-based biosensors sometime suffer from false positive signals and unexpected off-target turn-on in biological environments,which are likely due to the unstable nature of the RNA site.Ways to control DNAzyme activity in order to improve the sensing performance remain a significant challenge.To meet the challenge,there is growing interest to develop synthetic strategies that can cage native DNAzyme under undesired conditions and reactivate it in target environment in order to function in a controlled manner.A variety of caging-decaging strategies have been developed to realize spatiotemporal control of the DNAzyme activity,improving its specificity and sensitivity as well as extending its application regimes In this review,we focus on strategies to regulate the catalytic activity of DNAzyme,highlight the nucleic acid modification chemistries,and summarize three strategies to cage DNAzyme functions.Examples of using caged DNAzyme for bio-applications have also been reviewed in detail.Finally,we provide our perspectives on the potential challenges and opportunities of this emerging research topic that could advance the DNAzyme field.
文献关键词：
中图分类号：
作者姓名：
ZHANG Qian;LIANG Yuyan;XING Hang
作者机构：
Institute of Chemical Biology and Nanomedicine,State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,P.R.China;College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,P.R.China;College of Biology,Hunan University,Changsha 410082,P.R.China
文献出处：
引用格式：
[1]ZHANG Qian;LIANG Yuyan;XING Hang-.Caging-Decaging Strategies to Realize Spatiotemporal Control of DNAzyme Activity for Biosensing and Bioimaging)[J].高等学校化学研究（英文版）,2022(04):902-911
A类：
Caging,Decaging,Biosensing,DNAzymes,caging,decaging
B类：
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AB值：
0.564398
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