MXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical appli-cations.These materials encompass alluring and manageable catalytic performances and physicochemical features,which make them suitable as(bio)sensors with high selectivity/sensitivity and efficiency.MXene-based structures with suitable electrical conductivity,biocompatibility,large surface area,optical/magnetic properties,and thermal/mechanical features can be applied in designing innovative nanozymes with area-dependent electrocatalytic performances.Despite the advances made,there is still a long way to deploy MXene-based nanozymes,especially in medical and healthcare applications;limitations pertaining the peroxi-dase-like activity and sensitivity/selectivity may restrict further practical applications of pristine MXenes.Thus,developing an efficient surface engineering tactic is still required to fabricate multifunctional MXene-based nanozymes with excellent activity.To obtain MXene-based nanozymes with unique physicochemical features and high stability,some crucial steps such as hybridization and modification ought to be performed.Notably,(nano)toxicological and long-term biosafety analyses along with clinical translation studies still need to be comprehensively addressed.Although very limited reports exist pertain-ing to the biomedical potentials of MXene-based nanozymes,the future explorations should transition toward the extensive research and detailed analyses to realize additional potentials of these structures in biomedicine with a focus on clinical and industrial aspects.In this perspective,therapeutic,diagnostic,and theranostic applications of MXene-based nanozymes are deliberated with a focus on future per-spectives toward more successful clinical translational studies.The current state-of-the-art biomedical advances in the use of MXene-based nanozymes,as well as their developmental challenges and future prospects are also highlighted.In view of the fascinating properties of MXene-based nanozymes,these materials can open significant new opportunities in the future of bio-and nanomedicine.

Siavash Iravani;Rajender S.Varma

Faculty of Pharmacy and Pharmaceutical Sciences,Isfahan University of Medical Sciences,Isfahan,Iran;Regional Centre of Advanced Technologies and Materials,Department of Physical Chemistry,Faculty of Science,Palacky University in Olomouc,?lechtitel(u)27,783 71 Olomouc,Czech Republic

纳微快报（英文）

[1]Siavash Iravani;Rajender S.Varma-.MXene-Based Composites as Nanozymes in Biomedicine:A Perspective)[J].纳微快报（英文）,2022(12):447-463

Nanozymes,Biomedicine,pertain

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