典型文献
Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance
文献摘要：
Organ transplant rejection(OTR)is a complex immune reaction involving multiple cells,and it determi-nes graft survival and patient prognosis.At present,most transplant recipients are administered a com-bination of immunosuppressive and biological agents to protect them from OTR.However,immunosuppressive agents negatively impact the immune system of the patients,causing them to suffer from serious complications,such as chronic infection and malignant tumors.Therefore,a thorough understanding of the mechanisms involved in immune tolerance and immune rejection with regard to organ transplant(OT)is essential for developing better treatment options and improving patient out-comes.This article reviews the role of immune cells in OTR and organ transplant tolerance(OTT),includ-ing the novel cell therapies that are currently under clinical trials for transplant recipients.
文献关键词：
中图分类号：
作者姓名：
Xiaojie Gan;Jian Gu;Zheng Ju;Ling Lu
作者机构：
Hepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University&Research Unit of Liver Transplantation and Transplant Immunology,Chinese Academy of Medical Sciences,Nanjing 210029,China
文献出处：
引用格式：
[1]Xiaojie Gan;Jian Gu;Zheng Ju;Ling Lu-.Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance)[J].工程（英文）,2022(03):44-56
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Diverse,Roles,Immune,Cells,Transplant,Rejection,Tolerance,Organ,transplant,rejection,OTR,complex,immune,reaction,involving,multiple,cells,determi,nes,graft,survival,prognosis,At,present,most,recipients,are,administered,bination,immunosuppressive,biological,agents,protect,them,from,However,negatively,impact,system,patients,causing,suffer,serious,complications,such,as,chronic,infection,malignant,tumors,Therefore,thorough,understanding,mechanisms,involved,tolerance,regard,organ,essential,developing,better,treatment,options,improving,out,comes,This,article,reviews,role,OTT,includ,novel,therapies,that,currently,clinical,trials
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0.653515
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