典型文献
Signature Based on Six Autophagy-related Genes to Predict Prognosis of Head and Neck Squamous Cell Carcinoma
文献摘要：
The present study aimed to develop an autophagy-related gene prognostic prediction model to provide survival risk prediction for head and neck squamous cell carcinoma(HNSCC)patients.Methods:The K-mean cluster analysis was performed on HNSCC samples based on the expression values of 210 autophagy-related genes for candidate signature gene selection.LASSO Cox regression analysis was generated using the potential genes and the risk score was calculated from the prognosis model.The risk score was processed as an independent prognostic indicator to construct the nomogram model.The immune status including immune cell infiltration ratio and checkpoints of patients with HNSCC in high-and low-risk groups was also explored.Results:LASSO Cox regression analysis was performed on the selected autophagy-related genes.According to the lambda value corresponding to the number of different genes in the LASSO Cox analysis,six genes(GABARAPL2,SAR1A,ST13,GAPDH,FADD and LAMP1)were finally chosen.The risk score based on the genes was generated,which was an independent prognostic marker for HNSCC.The prognostic prediction model(nomogram)was further optimized by the independent prognostic factors(risk score),which can better predict the prognosis and survival of patients.With the risk score and prognosis model,eight types of immune cells and six key immune checkpoints(CTLA4,PD1,IDO1,TDO2,LAG3,TIGIT)displayed expression specificity.Conclusion:This study identified several potential prognostic biomarkers and established an autophagy-related prognostic prediction model for HNSCC,which provides a valuable reference for future clinical research.
文献关键词：
中图分类号：
作者姓名：
Hua ZHANG;Liang ZHANG;Ya-tong FAN;Tian-ning LI;Li-su PENG;Kun-peng WANG;Jun MA
作者机构：
Clinical Laboratory Diagnostics,Tianjin Medical University General Hospital Airport Site,Tianjin 300308,China;Department of Health Statistics,Public Health School of Tianjin Medical University,Tianjin 300070,China;School and Hospital of Stomatology,Tianjin Medical University,Tianjin 300070,China;Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin 300070,China
文献出处：
引用格式：
[1]Hua ZHANG;Liang ZHANG;Ya-tong FAN;Tian-ning LI;Li-su PENG;Kun-peng WANG;Jun MA-.Signature Based on Six Autophagy-related Genes to Predict Prognosis of Head and Neck Squamous Cell Carcinoma)[J].当代医学科学(英文),2022(03):597-605
A类：
GABARAPL2,SAR1A
B类：
Signature,Based,Six,Autophagy,related,Genes,Predict,Prognosis,Head,Neck,Squamous,Cell,Carcinoma,present,study,aimed,develop,autophagy,prognostic,prediction,model,survival,risk,head,neck,squamous,carcinoma,HNSCC,patients,Methods,mean,cluster,analysis,was,performed,samples,expression,values,genes,candidate,signature,selection,LASSO,Cox,regression,generated,using,potential,score,calculated,from,prognosis,processed,independent,indicator,construct,nomogram,immune,status,including,infiltration,checkpoints,high,low,groups,also,explored,Results,selected,According,lambda,corresponding,number,different,six,ST13,GAPDH,FADD,LAMP1,were,finally,chosen,which,further,optimized,by,factors,better,With,eight,types,cells,key,CTLA4,PD1,IDO1,TDO2,LAG3,TIGIT,displayed,specificity,Conclusion,This,identified,several,biomarkers,established,provides,valuable,reference,future,clinical,research
AB值：
0.513252
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
