典型文献
Mono-2-ethylhexyl Phthalate Promotes Migration and Invasion by Regulating the Epithelial-Mesenchymal Transition in SH- SY5Y Cells
文献摘要：
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. It accounts for 8％–10％ of all malignant tumors in children[1] and results in a heavy burden to the life and health of children. NB is a complex disease, and its occurrence is related to exposure to environmental risk factors. Children of parents who are occupationally exposed to environmental endocrine disruptors (EEDs) such as paint have a significantly higher risk of NB[2]. Di-2-ethylhcxylphthalate (DEHP) is a widespread EED that can interfere with a variety of neurotransmitters, affect the differentiation, proliferation and migration of neurons, and cause damage to the nervous system, thereby increasing the risk of neurological tumors such as NB in children[3]. DEHP enters the human body, where it is metabolized into mono-2-ethylhexyl phthalate (MEHP). MEHP has been detected in human blood, breast milk, and urine. In a previous study, we found that MEHP promoted the proliferation of SH-SY5Y cells and upregulated matrix metalloproteinase-2 (MMP-2) and MMP-9 to promote the migration of SH-SY5Y cells[3]. However, the mechanism by which MEHP promotes the migration of SH-SY5Y cells remains unclear.
文献关键词：
中图分类号：
作者姓名：
XU Qi;ZHANG Bo;LI Xu;YE Jia Ming;HUO Chuan Yi;YIN Jian Li;ZHANG Ru Xuan;ZHAO Wei Sen;QI Wen;YE Lin
作者机构：
Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130000,Jilin, China;Department of Pediatric Neurology, the First Hospital of Jilin University, Changchun 130000, Jilin, China
文献出处：
引用格式：
[1]XU Qi;ZHANG Bo;LI Xu;YE Jia Ming;HUO Chuan Yi;YIN Jian Li;ZHANG Ru Xuan;ZHAO Wei Sen;QI Wen;YE Lin-.Mono-2-ethylhexyl Phthalate Promotes Migration and Invasion by Regulating the Epithelial-Mesenchymal Transition in SH- SY5Y Cells)[J].生物医学与环境科学（英文版）,2022(03):276-281
A类：
Phthalate,occupationally,EEDs,ethylhcxylphthalate
B类：
Mono,ethylhexyl,Promotes,Migration,Invasion,Regulating,Epithelial,Mesenchymal,Transition,SH,SY5Y,Cells,Neuroblastoma,NB,most,common,extracranial,solid,childhood,It,accounts,malignant,tumors,children,results,heavy,burden,health,complex,disease,its,occurrence,related,exposure,environmental,risk,factors,Children,parents,who,exposed,endocrine,disruptors,such,paint,have,significantly,higher,Di,DEHP,widespread,that,interfere,variety,neurotransmitters,affect,differentiation,proliferation,migration,neurons,cause,damage,nervous,system,thereby,increasing,neurological,enters,human,body,where,metabolized,into,mono,MEHP,has,been,detected,blood,breast,milk,urine,previous,study,found,promoted,cells,upregulated,matrix,metalloproteinase,MMP,However,mechanism,which,promotes,remains,unclear
AB值：
0.58803
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
